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In addition to the plant's insecticidal potential against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Tribolium castaneum<\/jats:italic>\n                    <\/jats:styled-content>\n                    , anti\u2010lipoxygenase activity, and cytotoxic activity against SAF\u20101 cell lines, this study evaluated the antioxidant capacity of the essential oil, whose chemical composition was previously published in our paper. The observed antioxidant effect may be related to the reducing capacity and the strong electron donating properties of the essential oil components and may partially explain the insecticidal activity found, with a recorded 70.70% repellency after 1\u2009h of exposure to the essential oil, compared with the control. The essential oil exhibited notable in\u00a0vitro anti\u2010lipoxygenase activity, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 0.01\u2009\u00b1\u20090.002\u2009\u03bcg\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    under the experimental conditions used. Moreover, molecular Docking outputs confirmed that the five main components of the essential oil bound well into the cavity of eukaryotic LOX\u20105 enzyme. Additionally, SAF\u20101 cell line cells were exposed to various concentrations of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M. marina<\/jats:italic>\n                    <\/jats:styled-content>\n                    essential oil. The findings indicate that the viability of SAF\u20101 cells was significantly affected only at a concentration of 5\u2009mg\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    . In conclusion, in addition to being a natural source of anti\u2010inflammatory chemicals for pharmaceutical uses,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Medicago marina<\/jats:italic>\n                    <\/jats:styled-content>\n                    essential oil may also be an environmentally beneficial way to keep stored goods safe from bug infestations. The biological activities observed may reflect the combined effects of the major constituents of the essential oil, particularly in relation to its pronounced insecticidal, cytotoxic, antioxidant and anti\u2010lipoxygenase effects.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72373","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:51:19Z","timestamp":1790250679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sea Medick Volatile Oil: Antioxidant, Insecticidal, In\u00a0Vitro Cytotoxic Activity on SAF\u20101 Cells and Anti\u2010Lipoxygenase Assessment via In\u00a0Vitro and In Silico Methods"],"prefix":"10.1002","volume":"14","author":[{"given":"Marwa","family":"Melliti","sequence":"first","affiliation":[{"name":"Laboratory of Transmissible Diseases and Biologically Active Substances (LR99 ES27), Faculty of Pharmacy University of Monastir  Monastir 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