{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:59:09Z","timestamp":1790405949893,"version":"4.1.0"},"reference-count":93,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n The rising demand for sustainable cosmeceuticals has driven us to explore the botanical source for anti\u2010aging application. This comparative study explores the antioxidant mediated anti\u2010aging potential of two varieties of dates\n \n Phoenix dactylifera<\/jats:italic>\n <\/jats:styled-content>\n (Zahidi dates) and\n \n Phoenix dactylifera<\/jats:styled-content>\n L.\n <\/jats:italic>\n (Piarom dates), through both in\u00a0vitro and in silico analysis. It aims to evaluate antioxidant potential, inhibition of anti\u2010aging protein and binding interaction of phytochemicals against the target of anti\u2010aging proteins. To achieve this, total phenolic and flavonoid content was analyzed, and radical scavenging activity was determined by DPPH analysis. The antioxidant enzymes SOD, catalase and peroxidase activity were assessed. Results revealed higher phenolic (92\u2009\u00b1\u20091.15\u2009mg GAE\/g), flavonoid (39.2\u2009\u00b1\u20090.11\u2009mg\u2009CE\/g) and % inhibition of DPPH (81.2\u2009\u00b1\u20091.46) in\n \n Phoenix dactylifera<\/jats:italic>\n <\/jats:styled-content>\n as compared to\n \n Phoenix dactylifera<\/jats:styled-content>\n L.,\n <\/jats:italic>\n revealing its high antioxidant potential.\n \n Phoenix dactylifera<\/jats:italic>\n <\/jats:styled-content>\n exhibited a greater anti\u2010aging potential against ECM\u2010degrading proteins than\n \n Phoenix dactylifera<\/jats:styled-content>\n L\n <\/jats:italic>\n ., as evidenced by the inhibition percentages of elastase (49.69%\u2009\u00b1\u20091.15%), hyaluronidase (51.65%\u2009\u00b1\u20091.49%) and collagenase (58.41%\u2009\u00b1\u20091.98%). LCMS analysis identified key phytochemicals that are madecassoside, glutaric acid, benzoquinoline, myrtenol and pimelic acid. FTIR and UV spectroscopy confirmed the presence of hydroxyl and phenolic compounds. These in\u00a0vitro analyses were further validated by in silico pharmacokinetics that suggest the majority of phytochemicals have high skin permeability, high GI absorption and suitable bioavailability scores, with phosphatidylcholine (\n \n Phoenix dactylifera<\/jats:styled-content>\n L\n <\/jats:italic>\n .) having a LogKp value of \u22120.27, and furostane (\n \n Phoenix dactylifera<\/jats:italic>\n <\/jats:styled-content>\n ) having a LogKp value of \u22123.16. The molecular docking analysis revealed 6\u2010sec\u2010Butylquinoline (\n \n Phoenix dactylifera<\/jats:italic>\n <\/jats:styled-content>\n ) and isonipecotic acid (\n \n Phoenix dactylifera<\/jats:styled-content>\n L.)\n <\/jats:italic>\n outperforming with inhibition values reaching up to \u221211.8062 and \u221215.82\u2009kcal\/mol against ECM\u2010degrading protein targets. These findings support\n \n Phoenix dactylifera<\/jats:italic>\n <\/jats:styled-content>\n 's antioxidant mediated\u2010anti\u2010aging properties in comparison to\n \n Phoenix dactylifera<\/jats:styled-content>\n L\n <\/jats:italic>\n ., prompting subsequent in\u00a0vivo and clinical research to confirm its effectiveness.\n <\/jats:p>","DOI":"10.1002\/fsn3.72388","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:49:12Z","timestamp":1790052552000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Study of the Antioxidant Mediated Antiaging Properties of Endocarp Extracts From\n \n Phoenix dactylifera<\/i>\n <\/scp>\n and\n Phoenix dactylifera L<\/i>\n . via In Silico and In\u00a0Vitro Analysis"],"prefix":"10.1002","volume":"14","author":[{"given":"Farheen","family":"Asaad","sequence":"first","affiliation":[{"name":"Department of Basic Sciences (Section Biochemistry) University of Veterinary and Animal Sciences (Jhang Campus) Jhang Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5061-3284","authenticated-orcid":false,"given":"Mazhar","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences (Section Biochemistry) University of Veterinary and Animal Sciences (Jhang Campus) Jhang Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8059-9160","authenticated-orcid":false,"given":"Waqas","family":"Haider","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences (Section Biochemistry) University of Veterinary and Animal Sciences (Jhang Campus) Jhang Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0380-1332","authenticated-orcid":false,"given":"Naveed","family":"Munir","sequence":"additional","affiliation":[{"name":"Department of Biomedical Lab Sciences, School of Health Sciences University of Management and Technology Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha Gul","family":"Zafar","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences (Section Biochemistry) University of Veterinary and Animal Sciences (Jhang Campus) Jhang Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5524-7735","authenticated-orcid":false,"given":"Muhammad","family":"Riaz","sequence":"additional","affiliation":[{"name":"Department of Allied Health Sciences University of Sargodha Sargodha Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7199-0118","authenticated-orcid":false,"given":"Muhammad","family":"Arshad","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences (Section Biochemistry) University of Veterinary and Animal Sciences (Jhang Campus) Jhang Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7281-4781","authenticated-orcid":false,"given":"Muhammad Arfan","family":"Zaman","sequence":"additional","affiliation":[{"name":"Department of Pathobiology (Section Parasitology) University of Veterinary and Animal Sciences (Jhang Campus) Jhang Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences (Section Pharmacology) University of Veterinary and Animal Sciences (Jhang Campus) Jhang Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0482-0896","authenticated-orcid":false,"given":"Muhammad Adnan","family":"Ayub","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Sahiwal Sahiwal 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