{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:53:43Z","timestamp":1791359623949,"version":"4.3.1"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Diabetes mellitus (DM), a chronic metabolic disorder, is characterized by disrupted glucose homeostasis, and its escalating global prevalence underscores the critical need for safe dietary interventions. This study investigated the hypoglycemic and hepatoprotective potential of a novel formulation combining astaxanthin oil (AO) and fish oil (FO) as an adjuvant nutritional strategy. The efficacy of the AO\u2013FO complex was evaluated using the insulin\u2010resistant HepG2 cell model in\u00a0vitro and high\u2010fat diet (HFD)\u2010fed insulin\u2010resistant mice in\u00a0vivo. While individual treatments with AO and FO improved basic insulin sensitivity, their co\u2010administration exhibited enhanced efficacy in promoting cellular glucose consumption. Notably, the combined formulation was associated with changes in key glucose metabolism\u2010related indices, including glucose\u20106\u2010phosphate, pyruvate kinase, hexokinase, and significantly mitigated oxidative stress markers. In\u00a0vivo, the AO\u2010FO complex showed greater effects on decreasing fasting blood glucose, improving oral glucose tolerance, and ameliorating systemic dyslipidemia compared to singular oil treatments. Furthermore, histopathological evaluations revealed a marked attenuation of hepatic steatosis and pancreatic islet damage following the combined treatment. Collectively, these findings support the potential combined benefits of astaxanthin and omega\u20103 polyunsaturated fatty acids for improving glucose homeostasis, suggesting that the AO\u2013FO complex may be a candidate functional food for DM management.<\/jats:p>","DOI":"10.1002\/fsn3.72410","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:39:45Z","timestamp":1791358785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypoglycemic Effect of Astaxanthin Oil\u2013Fish Oil Complex in Mice With Type 2 Diabetes"],"prefix":"10.1002","volume":"14","author":[{"given":"Zhichao","family":"Lin","sequence":"first","affiliation":[{"name":"Third Institute of Oceanography Ministry of Natural Resource  Xiamen Fujian People's Republic of China"},{"name":"School of Advance Manufacturing\/School of Ocean Fuzhou University  Jinjiang Fujian People's Republic of 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