{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:01:01Z","timestamp":1790834461662,"version":"4.1.0"},"reference-count":95,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Aging is a natural, progressive physiological process accompanied by systemic multi\u2010organ dysfunction, for which effective intervention strategies remain limited.\n                    <jats:italic>Gastrodia elata<\/jats:italic>\n                    is a well\u2010known food and medicine homologous resource with extensive bioactive properties.\n                    <jats:italic>Gastrodia elata<\/jats:italic>\n                    polysaccharide (GEP), a bioactive macromolecule isolated from\n                    <jats:italic>G. elata<\/jats:italic>\n                    , is a promising candidate for the development of anti\u2010aging functional products. In this study, we first verified the preliminary anti\u2010aging effects of GEP in\u00a0vitro and in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    <\/jats:styled-content>\n                    , and further administered GEP to natural aging mice to explore its anti\u2010aging effects and underlying mechanisms. The results showed that GEP significantly alleviated\n                    <jats:sc>d<\/jats:sc>\n                    \u2010galactose (\n                    <jats:sc>d<\/jats:sc>\n                    \u2010gal)\u2010induced senescence of BV2 microglia, prolonged the lifespan of nematodes, and in aging mice, it markedly ameliorated cognitive impairment, muscle dysfunction, and hippocampal neuronal damage, while upregulating the expression of neuroprotective BDNF. Moreover, GEP reduced the level of malondialdehyde (MDA) and increased the activities of superoxide dismutase (SOD) and catalase (CAT), and activated the Nrf2\/Keap1 signaling pathway by downregulating Keap1 and upregulating HO\u20101 and NQO1, suggesting that GEP may ameliorate aging by reversing oxidative stress imbalance. GEP also significantly decreased the levels of pro\u2010inflammatory factors tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interleukin\u20101\u03b2 (IL\u20101\u03b2), and interleukin\u20106 (IL\u20106) in both serum and brain tissue, which may be the result of the alleviation of chronic inflammation by the inactivation of the TLR4\/NF\u2010\u03baB pathway. Furthermore, our results revealed a significant association between GEP\u2010mediated gut microbial remodeling and its neuroprotective phenotypes. GEP normalized aging\u2010induced gut dysbiosis, recovered microbial diversity, restored the abundance of beneficial genera including\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    and\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    , and elevated intestinal tight junction proteins ZO\u20101 and occludin. Such intestinal improvements may partially contribute to GEP's anti\u2010aging capacity through the gut\u2013brain axis, though definitive causal evidence such as fecal microbiota transplantation is lacking in the present study. Collectively, these findings provide a theoretical foundation for the development and application of GEP\u2010based functional products targeting aging intervention.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72413","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:40:49Z","timestamp":1790833249000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>\n                      <i>Gastrodia elata<\/i>\n                    <\/scp>\n                    Polysaccharide Attenuates Aging by Modulating Oxidative Stress, Inflammation, and Gut Microbiota"],"prefix":"10.1002","volume":"14","author":[{"given":"Huihuang","family":"Shi","sequence":"first","affiliation":[{"name":"Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology College of Agronomy and Life Sciences, Zhaotong University  Zhaotong China"},{"name":"Yunnan Engineering Research Center of Green Planting and Processing of Gastrodia College of Agronomy and Life Sciences, Zhaotong University  Zhaotong China"},{"name":"Yunnan Key Laboratory of Smart Villages and Agri\u2010Cultural\u2010Tourism Integration Zhaotong University  Zhaotong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunqiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology College of Agronomy and Life Sciences, Zhaotong University  Zhaotong China"},{"name":"Yunnan Engineering Research Center of Green Planting and Processing of Gastrodia College of Agronomy and Life Sciences, Zhaotong University  Zhaotong China"},{"name":"Yunnan Key Laboratory of Smart Villages and Agri\u2010Cultural\u2010Tourism Integration Zhaotong University  Zhaotong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0565-0288","authenticated-orcid":false,"given":"Yue","family":"Chen","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology College of Agronomy and Life Sciences, Zhaotong University  Zhaotong China"},{"name":"Yunnan Engineering Research Center of Green Planting and Processing of Gastrodia College of Agronomy and Life Sciences, Zhaotong University  Zhaotong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biting","family":"Shaog","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology College of Agronomy and Life Sciences, Zhaotong University  Zhaotong China"},{"name":"Yunnan Engineering Research Center of Green Planting and Processing of Gastrodia College of Agronomy and Life Sciences, Zhaotong University  Zhaotong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Gong","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology College of Agronomy and Life Sciences, Zhaotong University  Zhaotong China"},{"name":"Yunnan Engineering Research Center of Green Planting and Processing of Gastrodia College of Agronomy and Life Sciences, Zhaotong University  Zhaotong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2779-5343","authenticated-orcid":false,"given":"Zhu","family":"Li","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology College of Agronomy and Life Sciences, Zhaotong University  Zhaotong China"},{"name":"Yunnan Engineering Research Center of Green Planting and Processing of Gastrodia College of Agronomy and Life Sciences, Zhaotong University  Zhaotong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"issue":"3","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/s41591-024-03483-9","article-title":"Integrating the Environmental and Genetic Architectures of Aging and Mortality","volume":"31","author":"Argentieri M. 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