{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:51:50Z","timestamp":1791442310708,"version":"4.3.3"},"reference-count":61,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MC131"],"award-info":[{"award-number":["ZR2021MC131"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Alcoholic liver disease (ALD) is a major global health burden with limited therapeutic options. The primary aim of this study was to investigate the hepatoprotective effects of Maillard reaction products derived from\n                    <jats:italic>Perinereis aibuhitensis<\/jats:italic>\n                    (P\u2010MRPs) in a mouse model of chronic alcohol\u2010induced liver injury. Male ICR mice were fed a Lieber\u2013DeCarli alcoholic liquid diet for 6\u2009weeks with or without P\u2010MRPs administration. P\u2010MRPs intervention significantly reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, alleviated hepatic histopathological injury, restored antioxidant enzyme activities (superoxide dismutase and glutathione peroxidase), and lowered malondialdehyde and interleukin (IL\u20106, IL\u201018, and IL\u20101\u03b2) levels. Mechanistically, P\u2010MRPs treatment upregulated hepatic nuclear factor erythroid 2\u2010related factor 2 (NRF2), downregulated NF\u2010\u03baB p65 and tumor necrosis factor (TNF)\u2010\u03b1, and restored carnitine O\u2010palmitoyltransferase 1A (CPT1A) expression. Liver metabolomic analysis revealed that P\u2010MRPs administration increased N\u2010acyl amino acids and tryptophan\u2010derived metabolites while reversing alcohol\u2010induced accumulation of glycerophospholipids and acylcarnitines. In\u00a0vitro, P\u2010MRPs reduced ethanol\u2010induced ROS accumulation and attenuated ALT and AST leakage in AML12 hepatocytes. Compositional profiling identified 27 small\u2010molecule compounds with significant changes in P\u2010MRPs abundance, and a high proportion of small\u2010molecule peptides. Collectively, these findings suggest that P\u2010MRPs protect against ALD\u2010related liver injury, potentially through coordinated regulation of antioxidant, inflammatory, and lipid metabolic pathways, and provide a hypothesis\u2010generating framework for future mechanistic investigations.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72417","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:18:12Z","timestamp":1791440292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatoprotective Effects of Maillard Reaction Products From\n                    <i>Perinereis aibuhitensis<\/i>\n                    : Identification and Metabolomic Insights in a Mouse Model of Alcoholic Liver Disease"],"prefix":"10.1002","volume":"14","author":[{"given":"Tonglei","family":"Qiao","sequence":"first","affiliation":[{"name":"Ocean College Yantai Institute of China Agricultural 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