{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T08:33:15Z","timestamp":1793003595713,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The neuroprotective properties of edible bird's nest (EBN) are well established; however, its effects on neuronal growth remain unclear. In this study, we investigated the effects of enzyme\u2010digested EBN (EBND) on neurogenesis in the PC12 neuronal cell line. Although treatment with EBND alone did not significantly promote the differentiation of PC12 cells, it increased neurite outgrowth and neurofilament expression when co\u2010administered with nerve growth factor (NGF). Moreover, EBND significantly augmented the NGF\u2010induced phosphorylation of TrkA and ERK1\/2, which in turn activated CREB and increased brain\u2010derived neurotrophic factor (BDNF) expression. Notably, these effects of EBND were diminished by the TrkA inhibitor GW441756. Taken together, these findings suggest that combined treatment with EBND and NGF enhances neurogenesis in PC12 cells by activating the TrkA\u2010ERK\u2010CREB\u2010BDNF signaling pathway.<\/jats:p>","DOI":"10.1002\/fsn3.72419","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:50:27Z","timestamp":1791355827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enzyme\u2010Digested Edible Bird's Nest Promotes NGF\u2010Induced Differentiation of PC12 Cells by Activating the TrkA\u2010ERK1\/2\u2010CREB\u2010BDNF Signaling Pathway"],"prefix":"10.1002","volume":"14","author":[{"given":"Wen","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University  Beijing 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