{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T08:33:03Z","timestamp":1793003583370,"version":"4.5.0"},"reference-count":67,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Dyslipidemia is a major risk factor for cardiovascular disease. Studies have shown that vitamin E has therapeutic effects on lipid metabolism; however, findings remain inconsistent. This meta\u2010analysis aims to assess the effectiveness of vitamin E administration on the serum lipid panel in patients with dyslipidemia. A database search through January 2026 was conducted to identify relevant randomized controlled trials (RCTs). Relevant data, including triglycerides (TG), total cholesterol (TC), and low\u2010 and high\u2010density lipoprotein cholesterol (LDL\u2010C and HDL\u2010C), were extracted. The overall effect size was estimated using weighted mean differences (WMDs) with 95% confidence intervals (CIs) via a random\u2010effects model. The pooled analysis of 22 RCTs (33 intervention arms) demonstrated that vitamin E significantly lowered TG (WMD: \u22128.14\u2009mg\/dL,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.021) and raised HDL\u2010C (WMD: 1.08\u2009mg\/dL,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.037) in patients with dyslipidemia, whereas reductions in TC (WMD: \u22126.48\u2009mg\/dL,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.097) and LDL\u2010C (WMD: \u22129.06\u2009mg\/dL,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.063) were not significant overall. Exploratory subgroup analyses suggested that tocotrienols may exert greater lipid\u2010modifying effects than tocopherols, with potentially larger benefits observed at lower doses, among individuals with more pronounced baseline lipid abnormalities, and during shorter intervention periods. In conclusion, vitamin E supplementation in patients with dyslipidemia shows modest improvements in lipid profiles, mainly lowering TG and increasing HDL\u2010C, with less consistent effects on TC and LDL\u2010C. Tocotrienols may be more effective than tocopherols, suggesting possible isoform\u2010specific effects, but overall clinical impact appears limited and requires further confirmation.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72428","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:41:17Z","timestamp":1791358877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Vitamin E Administration on Serum Lipid Profile in Adult Patients With Dyslipidemia: A\n                    <scp>GRADE<\/scp>\n                    \u2010Assessed Systematic Review and Dose\u2013Response Meta\u2010Analysis of\n                    <scp>RCT<\/scp>\n                    s"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4388-0214","authenticated-orcid":false,"given":"Mehdi","family":"Karimi","sequence":"first","affiliation":[{"name":"Faculty of 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