{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:49:17Z","timestamp":1791524957705,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Honeybee (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Apis mellifera<\/jats:italic>\n                    <\/jats:styled-content>\n                    L.) podmore is an underutilized apicultural by\u2010product that may serve as a source of nutrients and bioactive compounds. This study evaluated the proximate composition and insulin secretion\u2010modulating potential of dried honeybee podmore. The results showed that podmore contained a high protein level (47.13\u2009g\/100\u2009g dry weight) and a considerable lipid content (19.28\u2009g\/100\u2009g dry weight). The amino acid profile was balanced, dominated by glutamic acid and aspartic acid, and contained substantial amounts of essential amino acids, particularly leucine, lysine, and valine. HPLC analysis revealed gallic acid (818.06\u2009\u03bcg\/g) and chlorogenic acid (225.04\u2009\u03bcg\/g) as the predominant compounds. Podmore extract exhibited notable antioxidant activity and showed concentration\u2010dependent inhibition of pancreatic lipase and \u03b1\u2010glucosidase, reaching 96.9% and 83.7% inhibition, respectively, at 1000\u2009\u03bcg\/mL. The extract enhanced insulin secretion in MIN6 pancreatic \u03b2 cells under both low\u2010 and high\u2010glucose conditions, with the highest response observed at 500\u2009\u03bcg\/mL under high\u2010glucose conditions. These findings suggest that dried honeybee podmore may be a promising source of nutritional and bioactive compounds with potential applications in the development of functional foods or nutraceuticals. However, further studies, including safety assessment, bioavailability evaluation, and in\u00a0vivo validation, are required before its practical application.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72471","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:54:21Z","timestamp":1791521661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemical Composition and In\u00a0Vitro Bioactive Potential of Dried Honeybee (\n                    <i>Apis mellifera<\/i>\n                    L.) Podmore as a Candidate Functional Food Ingredient"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7399-1277","authenticated-orcid":false,"given":"Marwa Rashad","family":"Ali","sequence":"first","affiliation":[{"name":"Food Science Department, Faculty of Agriculture Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2046-815X","authenticated-orcid":false,"given":"Esraa Naser","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Food Science Department, Faculty of Agriculture Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8056-7696","authenticated-orcid":false,"given":"Hatem Sharaf","family":"El\u2010Din","sequence":"additional","affiliation":[{"name":"Economic Entomology and Pesticides Department, Faculty of Agriculture Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8140-0473","authenticated-orcid":false,"given":"Rawaa H.","family":"Tlay","sequence":"additional","affiliation":[{"name":"Food Science Department, Faculty of Agricultural Engineering Damascus University  Damascus Syrian Arab Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7012-6667","authenticated-orcid":false,"given":"Tarek Gamal","family":"Abedelmaksoud","sequence":"additional","affiliation":[{"name":"Food Science Department, Faculty of Agriculture Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"issue":"12","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"10357","DOI":"10.1002\/fsn3.4581","article-title":"Drones and Workers of Honeybee \n                     Apis mellifera\n                   L. 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Promotes Pancreatic \u03b2\u2010Cell Proliferation and Insulin Secretion","volume":"12","author":"Yang S.","year":"2021","journal-title":"Frontiers in Pharmacology"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.72471","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.72471","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.72471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:54:26Z","timestamp":1791521666000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.72471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/fsn3.72471"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.72471","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72471"}}