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The capitula of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Coreopsis tinctoria<\/jats:italic>\n                    <\/jats:styled-content>\n                    Nutt. (CCT) are edible flowers rich in polyphenols, but their mood\u2010supporting efficacy remains unclear. This study investigated the effects, mechanisms, and key bioactive constituents of CCT polyphenol extract (CCTE) in a chronic unpredictable mild stress (CUMS) mouse model. High\u2010dose CCTE (1\u2009g\/kg) restored sucrose preference from 30.9%\u2009\u00b1\u20094.1% in CUMS mice to 52.0%\u2009\u00b1\u20095.5%, increased week\u20106 weight gain from 4.7%\u2009\u00b1\u20092.4% to 38.8%\u2009\u00b1\u20095.9% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and restored open\u2010field rearing, central\u2010area crossings, and residence time to fluoxetine\u2010comparable levels, indicating dose\u2010dependent attenuation of CUMS\u2010induced depressive\u2010like behaviors. It also ameliorated hippocampal neuronal damage, corrected the CUMS\u2010induced 36.7% reduction in serum 5\u2010HT and 44.8% elevation in 5\u2010HIAA, attenuated hypothalamic\u2013pituitary\u2013adrenal (HPA) hyperactivity, particularly reducing elevated CRH, ACTH, and CORT levels, alleviated oxidative stress, and suppressed NLRP3 inflammasome\u2013driven neuroinflammation via NLRP3\/NF\u2010\u03baB downregulation. Three flavonoid aglycones\u2014okanin (OKA), isookanin (ISO), taxifolin (TAX)\u2014crossed the blood\u2013brain barrier (free\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    28.45\u2009\u00b1\u200910.9, 32.74\u2009\u00b1\u200927.3, 32.04\u2009\u00b1\u20096.9\u2009ng\/g;\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    20\u201345\u2009min) and inhibited monoamine oxidase A (MAO\u2010A; IC\n                    <jats:sub>50<\/jats:sub>\n                    38.66\u2009\u00b1\u20092.45, 48.23\u2009\u00b1\u20093.12, 47.28\u2009\u00b1\u20092.98\u2009\u03bcmol\/L); their equimolar mixture acted synergistically (IC\n                    <jats:sub>50<\/jats:sub>\n                    18.79\u2009\u00b1\u20091.67\u2009\u03bcmol\/L; pargyline 8.71\u2009\u00b1\u20091.21\u2009\u03bcmol\/L,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Thus, CCTE ameliorates stress\u2010induced mood disturbances through multi\u2010target regulation and shows potential as a functional food ingredient.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72480","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:05:51Z","timestamp":1792152351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Coreopsis tinctoria<\/i>\n                    Nutt. Polyphenols Ameliorate\n                    <scp>CUMS<\/scp>\n                    \u2010Induced Depressive Behaviors and Hippocampal Neuronal Damage in Mice"],"prefix":"10.1002","volume":"14","author":[{"given":"Haixia","family":"Han","sequence":"first","affiliation":[{"name":"College of Food Science and Pharmacy Xinjiang Agricultural University  Urumqi China"},{"name":"Xinjiang Key Laboratory of Postharvest Fruit Science and Technology  Urumqi China"},{"name":"College of Modern Industry in Chinese Herbal Medicine Xinjiang Agricultural University  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Shanghai Punan Hospital of Pudong New District  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Pharmacy Xinjiang Agricultural University 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