{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:46:36Z","timestamp":1792028796333,"version":"4.4.0"},"reference-count":143,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The global population is expected to reach 9.7 billion by 2050, with demand for food increasing by up to 56%. Postbiotics are a safe and reliable substitute for probiotics, which are described as preparations of non\u2010viable bacteria and\/or their metabolic byproducts. Data for this narrative review was collected using Goggle scholar and PubMed from 2006 to 2026. Major bioactive compounds such as short\u2010chain fatty acids, peptides, polysaccharides, vitamins, and cell fragments contribute to immunomodulatory, antioxidant, metabolic, and gut\u2010brain axis effects. Preclinical and clinical research shows that they can improve insulin sensitivity, control cytokine signaling, strengthen epithelial barrier integrity, and protect against obesity, type 2 diabetes mellitus, and depression. Postbiotics have also been found to improve mineral absorption and folate synthesis, and possess anti\u2010sarcopenic actions. Several commercial products are available because of their health benefits. Thus, postbiotics are a revolutionary development in microbiome\u2010based treatments; however, to completely understand their therapeutic potential, it is necessary to standardize, achieve mechanistic clarity, and ensure regulatory alignment.<\/jats:p>","DOI":"10.1002\/fsn3.72485","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:36:41Z","timestamp":1792028201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postbiotics Unveiled: The Next Emerging Trend in Functional Foods"],"prefix":"10.1002","volume":"14","author":[{"given":"Zoha","family":"Wahid","sequence":"first","affiliation":[{"name":"Department of Human Nutrition and Dietetics NUST School of Health Sciences, National University of Sciences &amp; Technology (NUST)  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3499-902X","authenticated-orcid":false,"given":"Abdul Momin Rizwan","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition and Dietetics NUST School of Health Sciences, National University of Sciences &amp; Technology (NUST)  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0509-9519","authenticated-orcid":false,"given":"Farheen","family":"Zulfiqar","sequence":"additional","affiliation":[{"name":"Department of Food Science and Human Nutrition University of Veterinary and Animal Sciences  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Hassan Bin Usman","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Public Health PRIME Consulting  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6376-0007","authenticated-orcid":false,"given":"Nilab","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Curative Medicine Ghalib University  Herat Afghanistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"issue":"22","key":"e_1_2_20_2_1","doi-asserted-by":"crossref","first-page":"5983","DOI":"10.1080\/10408398.2021.1895061","article-title":"The Biological Activities of Postbiotics in Gastrointestinal Disorders","volume":"62","author":"Abbasi A.","year":"2022","journal-title":"Critical Reviews in Food Science and Nutrition"},{"issue":"7","key":"e_1_2_20_3_1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1080\/09637486.2021.1886255","article-title":"Effects of Urolithins on Obesity\u2010Associated Gut Dysbiosis in Rats Fed on a High\u2010Fat Diet","volume":"72","author":"Abdulrahman A. 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