{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T10:43:17Z","timestamp":1793356997337,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Alzheimer's disease (AD) is a progressive neurodegenerative disorder lacking effective and safe interventions. Food\u2010derived anthocyanins have gained increasing attention due to their neuroprotective potential; however, the specific mechanisms of individual cyanidin glycosides remain insufficiently understood. Notably, the comparative efficacy and mechanistic differences among structurally distinct cyanidin glycosides have not been systematically evaluated in\u00a0vivo. In the present study, three cyanidin glycosides, cyanidin\u20103\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010rutinoside (C3R), cyanidin\u20103\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010sophoroside (C3S), and cyanidin\u20103\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010xyloside (C3X), were evaluated using an aluminum chloride (AlCl\n                    <jats:sub>3<\/jats:sub>\n                    )\u2010induced zebrafish model of AD\u2010like pathology. The results showed that these compounds improved cognitive performance and anxiety\u2010like behavior, while attenuating oxidative stress and neuroinflammation and restoring cholinergic function, as evidenced by biochemical and immunofluorescence analyses. In addition, neuronal damage and Tau phosphorylation at Ser396 were markedly alleviated. Among the tested compounds, C3R consistently exhibited the most pronounced effects across multiple indicators. Mechanistically, the three cyanidin glycosides modulated PI3K\/Akt\/GSK3\u03b2 signaling, as reflected by overall increases in p\u2010PI3K (Tyr458)\/PI3K and p\u2010Akt (Ser473)\/Akt and decreases in p\u2010GSK3\u03b2 (Tyr216)\/GSK3\u03b2 and p\u2010Tau (Ser396)\/Tau. LY294002 attenuated the pathway\u2010associated protective effects, supporting the involvement of PI3K\/Akt signaling. Collectively, these findings demonstrate neuroprotective effects associated with modulation of PI3K\/Akt\/GSK3\u03b2 signaling, with C3R showing the strongest overall efficacy.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72486","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:27:20Z","timestamp":1792114040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroprotective Effects of Food\u2010Derived Cyanidin Glycosides in an Alzheimer's Disease\u2010Like Zebrafish Model Through Modulation of PI3K\/Akt\/GSK3\u03b2 Signaling"],"prefix":"10.1002","volume":"14","author":[{"given":"Yun","family":"Wu","sequence":"first","affiliation":[{"name":"Qinghai Provincial Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology Chinese Academy of Sciences  Xining China"},{"name":"University of Chinese Academy of Sciences  Beijing 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