{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:41:40Z","timestamp":1792215700273,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Decabromodiphenyl ethane (DBDPE) is an emerging brominated flame retardant that has been detected in animal\u2010derived foods. This exploratory experiment used a high\u2010dose toxicological challenge rather than a dietary\u2010exposure scenario. This study evaluated whether resveratrol (Res) pretreatment was associated with differences in selected liver\u2010 and kidney\u2010related endpoints in a high\u2010dose DBDPE mouse model. A total of 54 five\u2010week\u2010old specific pathogen\u2010free female Kunming mice were acclimated for 7\u2009days and allocated into six groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099) by weight\u2010ranked allocation. Res (25, 50, or 100\u2009mg\/kg body weight\/day; 100\u2009mg\/kg in the Res\u2010alone group) or vehicle was administered by oral gavage 2\u2009h before DBDPE (500\u2009mg\/kg body weight\/day) or corn oil, also by gavage, for 28 consecutive days. DBDPE exposure was associated with serum biochemical alterations, descriptive liver and kidney histological changes, redox imbalance, higher iron\u2010assay values, mitochondrial ultrastructural abnormalities, and changes in ferroptosis\u2010associated markers. The liver index was 5.06%\u2009\u00b1\u20090.20% in the Control group, 5.89%\u2009\u00b1\u20090.60% in the DBDPE group and 5.17%\u2009\u00b1\u20090.41% in the 100\u2009mg\/kg Res pretreatment group; the corresponding kidney indices were 1.02%\u2009\u00b1\u20090.10%, 1.16%\u2009\u00b1\u20090.07% and 1.06%\u2009\u00b1\u20090.03%. Res pretreatment was accompanied by lower values for several DBDPE\u2010associated endpoints, by changes in Pik3r1, Nfe2l2 and selected antioxidant\u2010related transcripts, and by tissue\u2010dependent changes in ferroptosis\u2010associated markers. These findings provide in\u00a0vivo associative evidence under the specified experimental conditions and support further evaluation of Res in DBDPE toxicology models; they do not establish ferroptotic cell death, PI3K\/Nrf2 pathway activation, or relevance to typical human dietary exposure.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.72495","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:07:16Z","timestamp":1792213636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Resveratrol Pretreatment and Decabromodiphenyl Ethane\u2010Associated Hepatorenal Changes in a High\u2010Dose Female Mouse Model: Redox Changes and Ferroptosis\u2010Associated Markers"],"prefix":"10.1002","volume":"14","author":[{"given":"Yutong","family":"Ji","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, College of Animal 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