{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:23:27Z","timestamp":1768004607205,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T00:00:00Z","timestamp":1534118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oxidative stress and antioxidant deficiency play a pivotal role in initiation, development, and outcomes of cardiovascular disease. Pharmacokinetic parameters as well as the impact of highly bioavailable lycopene on cardiovascular variables, markers of inflammation and oxidation were investigated during a 30\u2010day clinical trial in patients with coronary vascular disease. The patients were randomized into two major groups and were supplemented with a single 7\u00a0mg daily dose of lycopene ingested either in the form of lactolycopene (68 patients) or in the form of lycosome\u2010formulated <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> lycopene (74 patients). The endpoints included cardiovascular function parameters, serum lipids, and four markers of oxidative stress and inflammation. Ingestion of lycosome\u2010formulated lycopene increased serum lycopene levels by 2.9\u2010 and 4.3\u2010fold, respectively, after 2 and 4\u00a0weeks of the trial, whereas supplementation with lactolycopene upregulated serum lycopene by half\u2010fold only after 4\u00a0weeks of ingestion. Lycosome formulation of lycopene resulted by the end of the trial in a threefold reduction in <jats:italic>Chlamydia pneumoniae<\/jats:italic> IgG and reduction to the same degree of the inflammatory oxidative damage marker. The decrease in oxidized <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> caused by lycosome\u2010formulated lycopene was fivefold. Moreover, supplementation with lycosome\u2010formulated lycopene was accompanied by a significant increase in tissue oxygenation and flow\u2010mediated dilation by the end of the observational period. In contrast, lactolycopene did not cause any significant changes in the parameters studied. Therefore, enhanced bioavailability of lycopene promotes its antioxidant and anti\u2010inflammatory functions and endorses a positive effect of lycopene on cardiovascular system.<\/jats:p>","DOI":"10.1002\/fsn3.734","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T05:29:19Z","timestamp":1534224559000},"page":"1770-1777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Effect of lycopene supplementation on cardiovascular parameters and markers of inflammation and oxidation in patients with coronary vascular disease"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8201-6863","authenticated-orcid":false,"given":"Ivan M.","family":"Petyaev","sequence":"first","affiliation":[{"name":"Lycotec Ltd  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel Y.","family":"Dovgalevsky","sequence":"additional","affiliation":[{"name":"Institute of Cardiology  Saratov Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor A.","family":"Klochkov","sequence":"additional","affiliation":[{"name":"Institute of Cardiology  Saratov Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalya E.","family":"Chalyk","sequence":"additional","affiliation":[{"name":"Institute of Cardiology  Saratov Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry V.","family":"Pristensky","sequence":"additional","affiliation":[{"name":"Lycotec Ltd  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina P.","family":"Chernyshova","sequence":"additional","affiliation":[{"name":"Lycotec Ltd  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruzan","family":"Udumyan","sequence":"additional","affiliation":[{"name":"Orebro University Hospital and School of Health and Medical Sciences Orebro University  \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taron","family":"Kocharyan","sequence":"additional","affiliation":[{"name":"Orebro University Hospital and School of Health and Medical Sciences Orebro University  \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel H.","family":"Kyle","sequence":"additional","affiliation":[{"name":"Lycotec Ltd  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina V.","family":"Lozbiakova","sequence":"additional","affiliation":[{"name":"Lycotec Ltd  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuriy K.","family":"Bashmakov","sequence":"additional","affiliation":[{"name":"Lycotec Ltd  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(06)70990-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijpvm.IJPVM_112_17"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/816307"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc8002"},{"key":"e_1_2_8_6_1","first-page":"509","article-title":"The Assessment of Flow\u2010Mediated Dilation (FMD) of the brachial artery","volume":"33","author":"Bianchini E.","year":"2006","journal-title":"Computers in Cardiology"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.02.033"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.01.009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40292-015-0081-8"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01746-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2016.04.037"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.08.122"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112459"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300130-JLR200"},{"issue":"4","key":"e_1_2_8_15_1","first-page":"263","article-title":"Lycopene \u2013 antioxidant with radioprotective and anticancer properties. 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