{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:55:52Z","timestamp":1791986152491,"version":"4.4.0"},"reference-count":64,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was designed to observe the possible protective effects of a triple\u2010fermented barley (<jats:italic>Hordeum vulgare<\/jats:italic> L.) extract (<jats:styled-content style=\"fixed-case\">FB<\/jats:styled-content>e) obtained by saccharification and using <jats:italic>Saccharomyces cerevisiae<\/jats:italic> and <jats:italic>Weissella cibaria<\/jats:italic> in alleviating gastric damage induced by a hydrochloric acid (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>l) and ethanol (Et<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>) mixture in mice. After oral administration of <jats:styled-content style=\"fixed-case\">FB<\/jats:styled-content>e (300, 200, and 100\u00a0mg\/kg) followed by 1\u00a0hr before and after the single treatment of <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>l\/Et<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> (H\/E) mixture, the hemorrhagic lesion scores, histopathology of the stomach, gastric nitrate\/nitrite content, lipid peroxidation, and antioxidant defense systems including catalase and superoxide dismutase activities were observed. Following a single oral treatment of H\/E\u2010induced gastric damages as measured by hemorrhagic gross lesions and histopathological gastric, ulcerative lesions were significantly and dose\u2010dependently (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01 or <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) inhibited in mice, when all three different doses of <jats:styled-content style=\"fixed-case\">FB<\/jats:styled-content>e were administered as compared to those in H\/E control mice. In particular, <jats:styled-content style=\"fixed-case\">FB<\/jats:styled-content>e also increased gastric nitrate\/nitrite content and strengthened the antioxidant defense, with a decrease in the level of gastric lipid peroxidation, but increased the activities of <jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>. Moreover, the effects of <jats:styled-content style=\"fixed-case\">FB<\/jats:styled-content>e are comparable to that of ranitidine, a reference drug. The obtained results suggest that this fermented barley extract prevented mice from H\/E\u2010induced gastric mucosal damages through the suppression of inflammatory responses and oxidative stress\u2010responsive free radicals. Thus, <jats:styled-content style=\"fixed-case\">FB<\/jats:styled-content>e can be useful to treat patients suffering from gastric mucosal disorders as a potent food supplement, and thereby, it would increase the necessity of application in the food industry.<\/jats:p>","DOI":"10.1002\/fsn3.745","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T04:33:57Z","timestamp":1538454837000},"page":"2036-2046","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Protective effects of a triple\u2010fermented barley extract (<scp>FB<\/scp>e) against <scp>HC<\/scp>l\/Et<scp>OH<\/scp>\u2010induced gastric mucosa damage in mice"],"prefix":"10.1002","volume":"6","author":[{"given":"Jong\u2010Min","family":"Lim","sequence":"first","affiliation":[{"name":"#305 Marine Bio\u2010Industry Development Center Glucan Corp.  Gijan\u2010gun Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Hyun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology College of Korean Medicine Daegu Haany University  Gyeongsan\u2010si Gyeongsanbuk\u2010do Korea"},{"name":"MRC\u2010GHF, College of Korean Medicine Daegu Haany University  Gyeongsan\u2010si Gyeongsanbuk\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology College of Korean Medicine Daegu Haany University  Gyeongsan\u2010si Gyeongsanbuk\u2010do Korea"},{"name":"MRC\u2010GHF, College of Korean Medicine Daegu Haany University  Gyeongsan\u2010si Gyeongsanbuk\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Chan","family":"Park","sequence":"additional","affiliation":[{"name":"#305 Marine Bio\u2010Industry Development Center Glucan Corp.  Gijan\u2010gun Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung\u2010Rae","family":"Cho","sequence":"additional","affiliation":[{"name":"#305 Marine Bio\u2010Industry Development Center Glucan Corp.  Gijan\u2010gun Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go\u2010Woon","family":"Jung","sequence":"additional","affiliation":[{"name":"#305 Marine Bio\u2010Industry Development Center Glucan Corp.  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