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Copper organic acid chelate, the only treatment to show striking and sustained reactive oxygen species generation, had the greatest impact on ubiquitinated proteins, reduced autophagy, and increased aggresome formation, reducing growth in both cell lines. The least effect was noted in copper proteinate with negligible impact on aggresome formation or extended growth for either cell line.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The type and source of copper can impact significantly at the cellular level.<\/jats:p><\/jats:sec>","DOI":"10.1002\/fsn3.857","type":"journal-article","created":{"date-parts":[[2018,10,21]],"date-time":"2018-10-21T04:11:07Z","timestamp":1540095067000},"page":"2499-2514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Acute exposure to organic and inorganic sources of copper: Differential response in intestinal cell lines"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0047-4268","authenticated-orcid":false,"given":"Joanne","family":"Keenan","sequence":"first","affiliation":[{"name":"National Institute for Cellular Biotechnology Dublin City University Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finbarr","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"National Institute for Cellular Biotechnology Dublin City University Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Henry","sequence":"additional","affiliation":[{"name":"National Institute for Cellular Biotechnology Dublin City University Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Breen","sequence":"additional","affiliation":[{"name":"National Institute for Cellular Biotechnology Dublin City University Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padraig","family":"Doolan","sequence":"additional","affiliation":[{"name":"National Institute for Cellular Biotechnology Dublin City University Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indre","family":"Sinkunaite","sequence":"additional","affiliation":[{"name":"Alltech Dunboyne Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Meleady","sequence":"additional","affiliation":[{"name":"National Institute for Cellular Biotechnology Dublin City University Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Clynes","sequence":"additional","affiliation":[{"name":"National Institute for Cellular Biotechnology Dublin City University Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Horgan","sequence":"additional","affiliation":[{"name":"Alltech Dunboyne Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Murphy","sequence":"additional","affiliation":[{"name":"Alltech Dunboyne Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3923\/ijps.2009.291.298"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.11648\/j.avs.20140203.11"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705821"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejar.2012.08.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejar.2012.08.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0716-97602006000100020"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.020289"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/03602530802431439"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00210.2004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2016.02.006"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.152363"},{"issue":"1","key":"e_1_2_8_13_1","first-page":"12","article-title":"Surveillance for waterborne\u2010disease outbreaks\u2014United States, 1993\u20131994","volume":"45","author":"Centers for Disease Control and Prevention (CDC)","year":"1996","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2016.4563"},{"issue":"8","key":"e_1_2_8_15_1","first-page":"1","article-title":"Heavy metal contamination of animal feedstuffs \u2013 A new survey","volume":"5","author":"Elliot S.","year":"2017","journal-title":"Journal of Applied Animal Nutrition"},{"key":"e_1_2_8_16_1","unstructured":"European Medicines Agency (EMEA)(2007).Guidelines on the specification limits for residues of metal catalysts. 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