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The experiment used a total of 60 ICR mice, which were divided into six groups. Except for the intact control groups, all groups received a single intraperitoneal injection of CCl<jats:sub>4<\/jats:sub> after a 7\u00a0day pre\u2010treatment period with distilled water, BH extracts, or silymarin. Twenty\u2010four hours after the CCl<jats:sub>4<\/jats:sub> injection, the following observations, representative of classical oxidative stress\u2010mediated centrolobular necrotic acute liver injuries, were observed: decreased body weight; small nodule formation and enlargement on the gross inspections with related liver weight increase; elevation of serum AST and ALT, increases in hepatic lipid peroxidation and related depletion of endogenous antioxidants and antioxidative enzymes; centrolobular necrosis; increases in apoptotic markers, lipid peroxidation markers, and oxidative stress markers. However, liver damage was significantly inhibited by the pre\u2010treatment with BH extracts. The present study demonstrated that oral administration of BH extracts prior to exposure to CCl<jats:sub>4<\/jats:sub> conferred favorable hepatoprotective effects. These results demonstrated that BHe possessed suitable properties for use as a potent hepatoprotective medicinal food.<\/jats:p>","DOI":"10.1002\/fsn3.893","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T08:02:41Z","timestamp":1543305761000},"page":"322-338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Hepatoprotective effects of blue honeysuckle on CCl<sub>4<\/sub>\u2010induced acute liver damaged mice"],"prefix":"10.1002","volume":"7","author":[{"given":"You\u2010Suk","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition College of BioNano Technology Gachon University  Seongnam\u2010si Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il Je","family":"Cho","sequence":"additional","affiliation":[{"name":"The Medical Research Center for Globalization of Herbal Formulation Department of Herbal Formulation College of Oriental Medicine Daegu Haany University  Gyeongsan\u2010si Gyeongdanuk\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Wan","family":"Kim","sequence":"additional","affiliation":[{"name":"Aribio Co. 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