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To ascertain the number and location of other genome alterations, we used 191 polymorphic markers in a genome\u2010wide search for loss of heterozygosity (LOH) in 31 Burkitt lymphoma cell lines and their normal counterparts. We were able to distinguish two types of altered allelic patterns: a bona fide LOH profile, indicative of deletion (LOH), and a profile indicative of increased dosage (ID). The former type was most frequent at chromosome arm 17p, most likely indicating <jats:italic>TP53<\/jats:italic> gene inactivation. Increased dosage at 1q was found almost exclusively in non\u2010EBV cell lines (<jats:italic>P<\/jats:italic> &lt; 0.00004) and correlated well with karyotypic abnormalities affecting region 1q21\u201025. Our results suggest that a gene important for BL pathogenesis is located in region 1q21\u201025 and that the activation of this gene mimics the effects of EBV. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10022","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T16:33:59Z","timestamp":1030293239000},"page":"217-224","source":"Crossref","is-referenced-by-count":12,"title":["Genome\u2010wide search for loss of heterozygosity in Burkitt lymphoma cell 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