{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:26:36Z","timestamp":1776108396837,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,1,23]],"date-time":"2002-01-23T00:00:00Z","timestamp":1011744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Double minute chromosomes (dmin) are small chromatin bodies consisting of genes amplified in an extrachromosomal location. dmins are uncommon in hematologic malignancies; they are seen primarily in acute myeloid leukemia, with amplification of the <jats:italic>MYC<\/jats:italic> oncogene or, less frequently, the <jats:italic>MLL<\/jats:italic> transcription factor. Nine patients with hematologic malignancies with dmin were seen at the Roswell Park Cancer Institute between 1985 and 2000; eight had acute myeloid leukemia and one a myelodysplastic syndrome. Fluorescence in situ hybridization (FISH) demonstrated <jats:italic>MYC<\/jats:italic> amplification on dmin in four patients, but <jats:italic>MLL<\/jats:italic> amplification was not seen. Spectral karyotyping showed that the dmin derived from chromosome 11 in one patient and from chromosome 19 in two others without <jats:italic>MYC<\/jats:italic> or <jats:italic>MLL<\/jats:italic> amplification; derivation from these chromosomes was confirmed by FISH with chromosome paint probes. The dmin of chromosome 11 origin hybridized to a bacterial artificial chromosome (BAC) RP11\u2010112M22 that maps to 11q24.3 and is predicted to contain <jats:italic>ETS1<\/jats:italic> and other markers, including <jats:italic>D11S11351<\/jats:italic> and <jats:italic>D11S4091<\/jats:italic>. The dmin of chromosome 19 origin in one patient hybridized to BACs RP11\u201046I12 and RP11\u2010110J19; in the other patient, these clones did not hybridize with the dmin, but were found to be amplified on a marker chromosome that was derived from chromosome 19 in that patient's cells. These BACs have been mapped to 19q12\u201319q13.1 and 19q11\u201319q13.1, respectively, and are predicted to contain the markers <jats:italic>D19S409<\/jats:italic> and <jats:italic>D19S919<\/jats:italic> and the gene for ubiquinol\u2010cytochrome C reductase, Rieske iron\u2010sulfur polypeptide1 (<jats:italic>UQCRFS1<\/jats:italic>). dmin originating from chromosome 19 have not been reported previously in hematologic malignancies. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10038","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:13:41Z","timestamp":1030317221000},"page":"42-47","source":"Crossref","is-referenced-by-count":47,"title":["Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndrome: Identification of new amplification regions by fluorescence in situ hybridization and spectral karyotyping"],"prefix":"10.1002","volume":"34","author":[{"given":"Sheila N.J.","family":"Sait","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misbah U.","family":"Qadir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M.","family":"Conroy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sei\u2010Ichi","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma J.","family":"Nowak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria R.","family":"Baer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,1,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1995.tb02442.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)90907-9"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199811)23:3<267::AID-GCC10>3.0.CO;2-J"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(88)90120-8"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(82)90043-7"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(85)90155-4"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1982.tb02771.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-4-620"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb04444.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19960822)69:4<247::AID-IJC1>3.0.CO;2-X"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.16.120182.000321"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(98)00260-X"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(99)00018-7"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05183.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(97)00119-7"},{"key":"e_1_2_5_17_1","volume-title":"An international system for human cytogenetic nomenclature","author":"ISCN","year":"1995"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910620107"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910320411"},{"key":"e_1_2_5_20_1","first-page":"7021","article-title":"Identification and characterization of a 19q12 amplicon in esophageal adenocarcinomas reveals cyclin E as the best candidate for this amplicon","volume":"60","author":"Lin L","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198009183031221"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980105)75:1<34::AID-IJC6>3.0.CO;2-2"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(98)00133-2"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870080308"},{"key":"e_1_2_5_25_1","first-page":"193","article-title":"Double minute chromosomes contain amplified c\u2010myc oncogene sequences in acute myeloid leukemia","volume":"10","author":"Mohamed AN","year":"1996","journal-title":"Hematopathol Mol Hematol"},{"key":"e_1_2_5_26_1","first-page":"1007","article-title":"Double minute chromosomes in acute myeloblastic leukemia","volume":"74","author":"Oguma N","year":"1985","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90152-X"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(94)00143-Y"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(98)00160-5"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197101)27:1<160::AID-CNCR2820270124>3.0.CO;2-X"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(80)90059-X"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870090111"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.53.070184.002311"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(200004)27:4<380::AID-GCC7>3.0.CO;2-#"},{"key":"e_1_2_5_35_1","first-page":"469","article-title":"Amplification of c\u2010MYC oncogene and point mutation of N\u2010RAS oncogene point mutation in acute myelocytic leukemias with double minute chromosomes","volume":"7","author":"Tanaka K","year":"1993","journal-title":"Leukemia"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.17.8165"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(82)90035-8"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.10038","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.10038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T09:02:43Z","timestamp":1696842163000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.10038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1,23]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["10.1002\/gcc.10038"],"URL":"https:\/\/doi.org\/10.1002\/gcc.10038","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1,23]]}}}