{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:31:49Z","timestamp":1773660709104,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,2,11]],"date-time":"2002-02-11T00:00:00Z","timestamp":1013385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chromosome bands 1p36 and 3p21 are known to be recurring breakpoints in therapy\u2010related (t\u2010) leukemia. We identified a recurring translocation, t(1;3)(p36;p21), in eight patients with various hematologic malignancies: three patients with ALL, one with chronic myelogenous leukemia (CML) in accelerated phase (AP), two with MDS, and two with AML(M3). Five of the eight patients had a history of chemotherapy, including alkylating agents in three, before the translocation was detected. In two of these five patients, the t(1;3)(p36;p21) emerged only at relapse or in the accelerated phase of CML. The karyotypes of the patients were complex, including \u22127 and structural abnormalities of 5q, 6q, 7q, 9p, and 11q23. Survival time varied among patients (25 days to more than 16 years). Using FISH with 13 1p35\u201336 cosmid probes (tel\u2014FB12\u2013CA5\u2013G7\u2013FD2\u2013CB1\u2013ED8\u2013FD9\u2013G32\u2013AE3\u2013G50\u2013AD8\u2013GG4\u2013G43\u2014cen), we delineated the 1p36 breakpoint in two patients with MDS and ALL as lying between FB12 and FD2 (between BAC47P3 and PAC963K15), with a small deletion near the breakpoint in both cases. In the patient with MDS, there was also a deletion at 3p21.3, as detected with the cosmid probe cosNRL9. The results of the present study suggest that t(1;3)(p36;p21) in hematologic diseases is associated with prior exposure to mutagens, including alkylating agents. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10055","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:24:15Z","timestamp":1030317855000},"page":"186-192","source":"Crossref","is-referenced-by-count":14,"title":["t(1;3)(p36;p21) is a recurring therapy\u2010related translocation"],"prefix":"10.1002","volume":"34","author":[{"given":"Yuko","family":"Sato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirakazu","family":"Kanamori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasusada","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Larson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle M.","family":"Le Beau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiya","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet D.","family":"Rowley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,2,11]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"An International System for Human Cytogenetic Nomenclature Basel","author":"ISCN","year":"1995"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2001.6511"},{"key":"e_1_2_6_4_1","first-page":"691a","article-title":"Large deletions 5\u2032 to ETO breakpoint were observed in 10% of patients with t(8;21)\u2010positive AML","volume":"96","author":"Godon C","year":"2000","journal-title":"Blood"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199703)18:3<200::AID-GCC6>3.0.CO;2-5"},{"key":"e_1_2_6_6_1","first-page":"547","article-title":"Heterogeneity of breakpoints of 11q23 rearrangements in hematologic malignancies identified with fluorescence in situ hybridization","volume":"82","author":"Kobayashi H","year":"1993","journal-title":"Blood"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01724.x"},{"key":"e_1_2_6_8_1","first-page":"395","volume-title":"The ACT cytogenetics laboratory manual","author":"Le Beau MM","year":"1991"},{"key":"e_1_2_6_9_1","first-page":"6116","article-title":"The 630\u2010kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium","volume":"60","author":"Lerman MI","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_6_10_1","unstructured":"MitelmanF JohanssonB MertensF editors.2001. Mitelman Database of Chromosome Aberrations in Cancer.http:\/\/cgap.nci.nih.gov\/Chromosomes\/Mitelman."},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1182\/blood.V96.9.3209","article-title":"A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS\/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)\u2010positive leukemia cells","volume":"96","author":"Mochizuki N","year":"2000","journal-title":"Blood"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.23.9358"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10040"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1182\/blood.V95.3.1066.003k11_1066_1068","article-title":"Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy\u2010related leukemia with t(3;11)(p21;q23)","volume":"95","author":"Sano K","year":"2000","journal-title":"Blood"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(91)90189-2"},{"key":"e_1_2_6_16_1","first-page":"4886","article-title":"Heterogeneity in the breakpoints in balanced rearrangements involving band 12p13 in hematologic malignancies identified by fluorescence in situ hybridization: TEL(ETV6) is involved in only one half","volume":"90","author":"Sato Y","year":"1997","journal-title":"Blood"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402188"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000134439"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(200003)27:3<229::AID-GCC2>3.0.CO;2-0"},{"key":"e_1_2_6_20_1","first-page":"1487","article-title":"Construction of a 600\u2010kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG","volume":"56","author":"Wei MH","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000134197"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.10055","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.10055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T14:09:19Z","timestamp":1700316559000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.10055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2,11]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["10.1002\/gcc.10055"],"URL":"https:\/\/doi.org\/10.1002\/gcc.10055","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,2,11]]}}}