{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:49:31Z","timestamp":1790470171694,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,2,11]],"date-time":"2002-02-11T00:00:00Z","timestamp":1013385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chromosome band 6q21 is reported to be one of the most frequent target regions in T\u2010cell lymphoma for both translocations and deletions. To explore whether the breakpoint clustering in T\u2010cell malignancy indicates the presence of a common breakpoint region in 6q, we employed fluorescence in situ hybridization analysis using various YAC, BAC, and PAC clones aligned at 6q21\u201322. We identified two T\u2010cell lymphoma\/leukemia cell lines with different differentiation stages that had breakpoints within the same novel gene, <jats:italic>TCBA1<\/jats:italic> (<jats:italic>T<\/jats:italic>\u2010<jats:italic>c<\/jats:italic>ell lymphoma <jats:italic>b<\/jats:italic>reakpoint <jats:italic>a<\/jats:italic>ssociated target <jats:italic>1<\/jats:italic>). In a T\u2010cell lymphoblastic lymphoma cell line, HT\u20101, the <jats:italic>TCBA1<\/jats:italic> fused to <jats:italic>SUSP1<\/jats:italic> (SUMO\u20101\u2010specific protease), creating a <jats:italic>SUSP1\u2010TCBA1<\/jats:italic> chimeric gene. However, in an adult T\u2010cell leukemia cell line, ATN\u20101, no chimeric gene was detected, although aberrant <jats:italic>TCBA1<\/jats:italic> transcripts were produced. We conclude that <jats:italic>TCBA1<\/jats:italic> is a possible target gene for T\u2010cell lineage\u2010specific chromosome aberrations at 6q21. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10057","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:24:15Z","timestamp":1030317855000},"page":"175-185","source":"Crossref","is-referenced-by-count":31,"title":["Molecular cytogenetic analysis of the breakpoint region at 6q21\u201322 in T\u2010cell lymphoma\/leukemia cell lines"],"prefix":"10.1002","volume":"34","author":[{"given":"Hiroyuki","family":"Tagawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritsuro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Hosokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Seto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,2,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.2820690527"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199904)24:4<315::AID-GCC4>3.0.CO;2-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203018"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90243-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.5.1731"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1676542"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.2.613"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1182\/blood.V90.9.3714","article-title":"AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily","volume":"90","author":"Hillon J","year":"1997","journal-title":"Blood"},{"key":"e_1_2_6_10_1","first-page":"2775","article-title":"Deletion of 6q16\u2013q21 in human lymphoid malignancies: a mapping and deletion analysis","volume":"60","author":"Jackson A","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_6_11_1","first-page":"1481","article-title":"Chromosome abnormalities in adult T\u2010cell leukemia\/lymphoma: a karyotype review committee report","volume":"52","author":"Kamada N","year":"1992","journal-title":"Cancer 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