{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:09:08Z","timestamp":1764688148200},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,3,8]],"date-time":"2002-03-08T00:00:00Z","timestamp":1015545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>For a better understanding of genetic alterations in head and neck squamous cell carcinoma (HNSCC), we applied comparative genomic hybridization (CGH) in the analysis of 75 HNSCCs, comprised of 18 pharyngeal squamous cell carcinomas (PSCCs), 23 laryngeal squamous cell carcinomas (LSCCs), and 34 oral squamous cell carcinomas (OSCCs). The three subgroups of HNSCC showed significant differences in genetic alteration patterns. Overall, PSCC and LSCC had more copy number aberrations (CNAs) per tumor than did OSCC. Apparent differing patterns of high\u2010level amplification were also observed. The smallest recurrent chromosomal regions of high\u2010level amplification (\u226515% of cases) were 7q22, 8q24.1, and 11q12\u201313 in PSCC and 3q26.1\u201329 in OSCC. According to single frequency and combined frequencies of CNAs, we concluded that the most important chromosomal events for progression of head and neck cancer were +3q, +5p, +8q, and \u22123p for all subgroups of HNSCC; additionally, +7q, +17q, \u22129p, and \u221213q for PSCC; +7p, +9q, +11q12\u201313, +14q, and +17q for LSCC; and +1p and +11q12\u201313 for OSCC. To identify further important genetic alterations and the relationships among the alterations, we constructed oncogenetic tree models for tumor progression of HNSCC from CGH data using branching and distance\u2010based tree models. The tree models predicted that: (1) +3q21\u201329 was the most important early chromosomal event, and \u22123p, which occurred after +3q21\u201329, was also an important chromosomal event for all subsites of HNSCC; (2) +8q is the second most important early chromosomal event; (3) there may be at least three subgroups of HNSCC: one characterized by \u22123p, \u22129p, +7p, and \u221213q; another by +5p, +9qter, and +17p; and the other by +8q and +18p. These results suggest that different chromosomal aberrations may play a role in the initiation and\/or progression of different subgroups of HNSCC. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10062","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:24:15Z","timestamp":1030317855000},"page":"224-233","source":"Crossref","is-referenced-by-count":128,"title":["Genetic differences detected by comparative genomic hybridization in head and neck squamous cell carcinomas from different tumor sites: construction of oncogenetic trees for tumor progression"],"prefix":"10.1002","volume":"34","author":[{"given":"Qiang","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo Pei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven A.","family":"McCormick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhakti","family":"Datta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj","family":"Mahimkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Lazarus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro A.","family":"Sch\u00e4ffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Desper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stimson P.","family":"Schantz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,3,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199605)16:1<46::AID-GCC7>3.0.CO;2-3"},{"key":"e_1_2_5_3_1","first-page":"4365","article-title":"Increased number of chromosomal imbalances and high\u2010level DNA amplifications in mantle cell lymphoma are associated with blastoid variants","volume":"93","author":"Be\u00e0 S","year":"1999","journal-title":"Blood"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199805)22:1<79::AID-GCC11>3.0.CO;2-D"},{"key":"e_1_2_5_5_1","first-page":"5325","article-title":"Distinct patterns of chromosomal alterations in high\u2010 and low\u2010grade head and neck squamous cell carcinomas","volume":"56","author":"Bockm\u00fchl U","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_5_6_1","first-page":"5213","article-title":"Patterns of chromosomal alterations in metastasizing and nonmetastasizing primary head and neck carcinomas","volume":"57","author":"Bockm\u00fchl U","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199803)20:2<145::AID-HED8>3.0.CO;2-2"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(82)90010-3"},{"key":"e_1_2_5_9_1","first-page":"3055","article-title":"Frequent novel DNA copy number increase in squamous cell head and neck tumors","volume":"55","author":"Brzoska PM","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1985.tb00389.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.1999.6.37"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/10665270050514936"},{"key":"e_1_2_5_13_1","unstructured":"FelsensteinJ.1989. . 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