{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T13:26:06Z","timestamp":1777123566293,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,3,19]],"date-time":"2002-03-19T00:00:00Z","timestamp":1016496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health, Labor and Welfare of Japan","award":["9-2"],"award-info":[{"award-number":["9-2"]}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Kawano Medical Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The nucleoporin gene <jats:italic>NUP98<\/jats:italic> has been reported to be fused to 9 partner genes in hematologic malignancies with 11p15 translocations. The <jats:italic>NUP98\u2010HOXA9<\/jats:italic> fusion gene has been identified in acute myeloid leukemia (AML) and chronic myelogenous leukemia with t(7;11)(p15;p15). We report here a novel <jats:italic>NUP98<\/jats:italic> partner gene, <jats:italic>HOXA13,<\/jats:italic> in a patient with de novo AML having t(7;11)(p15;p15). The <jats:italic>HOXA13<\/jats:italic> gene is part of the <jats:italic>HOXA<\/jats:italic> cluster genes and contains 2 exons, encoding a protein of 338 amino acids with a homeodomain. The NUP98\u2010HOXA13 fusion protein consists of the N\u2010terminal phenylalanine\u2010glycine repeat motif of NUP98 and the C\u2010terminal homeodomain of HOXA13, similar to the NUP98\u2010HOXA9 fusion protein. Reverse transcriptase\u2013polymerase chain reaction (RT\u2010PCR) analysis in various leukemic cell lines showed that the <jats:italic>HOXA13<\/jats:italic> gene was expressed significantly more frequently in acute monocytic leukemic cell lines than in other leukemic cell lines (<jats:italic>P<\/jats:italic> = 0.039). <jats:italic>HOXA13<\/jats:italic> and three <jats:italic>HOXA<\/jats:italic> cluster genes (<jats:italic>A9, A10, A11<\/jats:italic>) located at the 5\u2032 end of the <jats:italic>HOXA9<\/jats:italic> gene were frequently expressed in myeloid leukemic cell lines. Our results revealed that t(7;11)(p15;p15) was not a single chromosomal abnormality at the molecular level. The protein encoded by the <jats:italic>NUP98\u2010HOXA13<\/jats:italic> fusion gene is similar to that encoded by <jats:italic>NUP98\u2010HOXA9,<\/jats:italic> and the expression pattern of the <jats:italic>HOXA13<\/jats:italic> gene in leukemic cell lines is similar to that of the <jats:italic>HOXA9<\/jats:italic> gene, suggesting that the NUP98\u2010HOXA13 fusion protein may play a role in leukemogenesis through a mechanism similar to that of the NUP98\u2010HOXA9 fusion protein. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10077","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T11:34:39Z","timestamp":1033904079000},"page":"437-443","source":"Crossref","is-referenced-by-count":48,"title":["The chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the <i>NUP98<\/i> gene with a <i>HOXA<\/i> cluster gene, <i>HOXA13<\/i>, but not <i>HOXA9<\/i>"],"prefix":"10.1002","volume":"34","author":[{"given":"Takeshi","family":"Taketani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Taki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohmei","family":"Ida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhide","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,6,25]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1182\/blood.V94.9.3258","article-title":"The 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