{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:06:15Z","timestamp":1766361975162,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,4,4]],"date-time":"2002-04-04T00:00:00Z","timestamp":1017878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swedish and Finnish Cancer Foundations"},{"name":"Torsten and Ragnar S\u00f6derberg Foundations"},{"DOI":"10.13039\/501100007231","name":"Cancer Society in Stockholm","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007231","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several types of endocrine tumors show frequent somatic deletions of the distal part of chromosome arm 11q, where the tumor\u2010suppressor gene <jats:italic>SDHD<\/jats:italic> (succinate\u2010ubiquinone oxidoreductase subunit D), constitutionally mutated in paragangliomas of the head and neck, is located. In this study, we screened 18 midgut carcinoids, 7 Merkel cell carcinomas, 46 adrenal pheochromocytomas (37 sporadic and 9 familial), and 7 abdominal paragangliomas for loss of heterozygosity (LOH) and\/or mutations at the <jats:italic>SDHD<\/jats:italic> gene locus. LOH was detected in 5 out of 8 (62%) informative midgut carcinoids, in 9 out of 30 (30%) sporadic pheochromocytomas, in none of the familial pheochromocytomas (0%), and in 1 out of 6 (17%) abdominal paragangliomas. No sequence variants were detected in the pheochromocytomas or paragangliomas. However, two constitutional putative missense mutations, H50R and G12S, were detected in two midgut carcinoids, which were both associated with LOH of the other allele. The same sequence variants were also detected in two Merkel cell carcinomas. In addition, the S68S polymorphism was found to coexist with the G12S sequence variant in both cases. In conclusion, we show that alterations of the <jats:italic>SDHD<\/jats:italic> gene seem to be involved in the tumorigenesis of both midgut carcinoids and Merkel cell carcinomas. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10081","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:27:00Z","timestamp":1030318020000},"page":"325-332","source":"Crossref","is-referenced-by-count":55,"title":["Alterations of the <i>SDHD<\/i> gene locus in midgut carcinoids, Merkel cell carcinomas, pheochromocytomas, and abdominal paragangliomas"],"prefix":"10.1002","volume":"34","author":[{"given":"Soili","family":"Kyt\u00f6l\u00e4","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brita","family":"Nord","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Edstr\u00f6m 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and occult germ\u2010line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial pheochromocytoma","volume":"60","author":"Gimm O","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990129)80:3<373::AID-IJC7>3.0.CO;2-B"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200521"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.1.216"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000134700"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2728(99)00071-7"},{"key":"e_1_2_6_16_1","first-page":"1301","article-title":"Analysis of changes in DNA sequence copy number by comparative genomic hybridization in archival paraffin\u2010embedded tumor samples","volume":"145","author":"Isola J","year":"1994","journal-title":"Am J 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