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The mean number of CIs per sample was 2.05 \u00b1 2.97, with gains (1.48 \u00b1 2.38) more frequent than losses (0.56 \u00b1 1.40). The common regions of gains were 18\/18q (50%), 7\/7p (42%), 3\/3q (33%), 20 (33%), 1p (25%), 12\/12q (25%), and 13\/13q (25%), whereas loss of 6q was frequent (42%). Among the different subsets of PCBCLs, CI was seen in 50% of diffuse large\u2010cell lymphomas (DLCLs), 33% of marginal zone lymphomas, and 8% of follicle center cell lymphomas and unclassified lymphomas. A similar pattern of CI was observed in these lymphomas, but loss of 6q and gains of 3\/3q were present only in DLCLs. Microarray\u2010based genomic analysis of four DLCL cases identified oncogene gains of <jats:italic>SAS\/CDK4<\/jats:italic> (12q13.3) in three cases and <jats:italic>MYCL1<\/jats:italic> (1p34.3), <jats:italic>MYC<\/jats:italic> (8q24), <jats:italic>FGFR2<\/jats:italic> (10q26), <jats:italic>BCL2<\/jats:italic> (18q21.3), <jats:italic>CSE1L<\/jats:italic> (20q13), and <jats:italic>PDGFB<\/jats:italic> (22q12\u201313) in two cases, whereas losses of <jats:italic>AKT1<\/jats:italic> (14q32.3), <jats:italic>IGFR1<\/jats:italic> (15q25\u201326), and <jats:italic>JUNB<\/jats:italic> (19p13.2) were identified in three cases, and losses of <jats:italic>FGR<\/jats:italic> (1p36), <jats:italic>ESR<\/jats:italic> (6q25.1), <jats:italic>ABL1<\/jats:italic> (9q34.1), <jats:italic>TOP2A<\/jats:italic> (17q21\u201322), <jats:italic>ERBB2<\/jats:italic> (17q21.2), <jats:italic>CCNE1<\/jats:italic> (19q13.1), and <jats:italic>BCR<\/jats:italic> (22q11) were each identified in two cases. In addition, real\u2010time\u2013polymerase chain reaction detected amplification of <jats:italic>BCL2<\/jats:italic> in 5 of 29 cases. These findings suggest that there are complex but consistent genetic alterations associated with the pathogenesis of PCBCLs. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10104","type":"journal-article","created":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T20:06:10Z","timestamp":1031256370000},"page":"144-155","source":"Crossref","is-referenced-by-count":83,"title":["Comparative genomic hybridization analysis of primary cutaneous B\u2010cell lymphomas: Identification of common genomic alterations in disease 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