{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:16:51Z","timestamp":1781237811135,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,9,15]],"date-time":"2002-09-15T00:00:00Z","timestamp":1032048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swedish Cancer Society"},{"name":"Gunnar Nilsson Cancer Fund"},{"name":"Medical Faculty of Lund University, Lund, Sweden"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The <jats:italic>NUP98<\/jats:italic> gene at 11p15 is known to be fused to <jats:italic>DDX10, HOXA9, HOXA11, HOXA13, HOXD11, HOXD13, LEDGF<\/jats:italic>, <jats:italic>NSD1, NSD3, PMX1<\/jats:italic>, <jats:italic>RAP1GDS1<\/jats:italic>, and <jats:italic>TOP1<\/jats:italic> in various hematologic malignancies. The common theme in all <jats:italic>NUP98<\/jats:italic> chimeras is a transcript consisting of the 5\u2032 part of <jats:italic>NUP98<\/jats:italic> and the 3\u2032 portion of the partner gene; however, apart from the frequent fusion to different homeobox genes, there is no apparent similarity among the other partners. We here report a de novo acute myeloid leukemia with a t(11;12)(p15;q13), resulting in a novel <jats:italic>NUP98\/HOXC13<\/jats:italic> fusion. Fluorescence in situ hybridization analyses, by the use of probes covering <jats:italic>NUP98<\/jats:italic> and the <jats:italic>HOXC<\/jats:italic> gene cluster at 12q13, revealed a fusion signal at the der(11)t(11;12), indicating a <jats:italic>NUP98\/HOXC<\/jats:italic> chimera, whereas no fusion was found on the der(12)t(11;12), suggesting that the translocation was accompanied by a deletion of the reciprocal fusion gene. Reverse transcription\u2010PCR and sequence analyses showed that exon 16 (nucleotide 2290) of <jats:italic>NUP98<\/jats:italic> was fused in\u2010frame with exon 2 (nucleotide 852) of <jats:italic>HOXC13<\/jats:italic>. Neither the <jats:italic>HOXC13\/NUP98<\/jats:italic> transcript nor the normal <jats:italic>HOXC13<\/jats:italic> was expressed. The present results, together with previous studies of <jats:italic>NUP98\/<\/jats:italic>homeobox gene fusions, strongly indicate that <jats:italic>NUP98\/HOXC13<\/jats:italic> is of pathogenetic importance in t(11;12)\u2010positive acute myeloid leukemia. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10139","type":"journal-article","created":{"date-parts":[[2002,12,3]],"date-time":"2002-12-03T13:50:22Z","timestamp":1038923422000},"page":"107-112","source":"Crossref","is-referenced-by-count":54,"title":["Fusion of the <i>NUP98<\/i> gene and the homeobox gene <i>HOXC13<\/i> in acute myeloid leukemia with t(11;12)(p15;q13)"],"prefix":"10.1002","volume":"36","author":[{"given":"Ioannis","family":"Panagopoulos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margareth","family":"Isaksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Billstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodil","family":"Str\u00f6mbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Mitelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertil","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,11,27]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1182\/blood.V94.9.3258","article-title":"The t(11;20)(p15;q11) chromosomal translocation associated with therapy\u2010related myelodysplastic syndrome results in an NUP98\u2010TOP1 fusion","volume":"94","author":"Ahuja HG","year":"1999","journal-title":"Blood"},{"key":"e_1_2_2_3_1","first-page":"6227","article-title":"t(9;11)(p22;p15) in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75\u2010lens epithelium\u2010derived growth factor (LEDGF)","volume":"60","author":"Ahuja HG","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000134320"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.11.3936"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0296-159"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.3782"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.4.1428"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.6.2072"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.4.1264"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101616200"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.1.764"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.3.350"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402269"},{"key":"e_1_2_2_15_1","unstructured":"MitelmanF JohanssonB MertensF.2002. Mitelman database of chromosome aberrations in cancer. May be accessed athttp:\/\/cgap.nci.nih.gov\/Chromosomes\/Mitelman"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0296-154"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.2.741"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199911)26:3<215::AID-GCC5>3.0.CO;2-1"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.4.395"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10066"},{"key":"e_1_2_2_21_1","first-page":"4269","article-title":"NUP98\u2010HOXD13 gene fusion in therapy\u2010related acute myelogenous leukemia","volume":"58","author":"Raza\u2010Egilmez SZ","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3857"},{"key":"e_1_2_2_23_1","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1182\/blood.V92.8.2879","article-title":"CBFA2(AML1) translocations with novel partner chromosomes in myeloid leukemias associated with prior therapy","volume":"92","author":"Roulston D","year":"1998","journal-title":"Blood"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10077"},{"key":"e_1_2_2_25_1","first-page":"33","article-title":"The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t(2;11)(q31;p15)","volume":"62","author":"Taketani T","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401562"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(97)00007-1"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.10139","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.10139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T14:12:46Z","timestamp":1697465566000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.10139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11,27]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1002\/gcc.10139"],"URL":"https:\/\/doi.org\/10.1002\/gcc.10139","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11,27]]}}}