{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:09:28Z","timestamp":1790377768941,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,3,17]],"date-time":"2003-03-17T00:00:00Z","timestamp":1047859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a search for genes specifically expressed in Reed\u2013Sternberg (RS) cells of Hodgkin lymphoma (HL), we applied the serial analysis of gene expression (SAGE) technique on the HL\u2010derived cell line DEV. Genes highly expressed in DEV were subjected to an RT\u2010PCR analysis to confirm the SAGE results. For one of the genes, a high expression was observed in DEV and other HL\u2010derived cell lines but not in non\u2010Hodgkin lymphoma (NHL)\u2013derived cell lines and normal controls, suggesting an HL\u2010specific expression. This gene corresponds to the human <jats:italic>BIC<\/jats:italic> gene, a member of the noncoding mRNA\u2010like molecules. RNA in situ hybridization (ISH) indicated an exclusive nucleolar localization of <jats:italic>BIC<\/jats:italic> transcripts in all RS cells in 91% of HL cases, including nodular lymphocyte predominance (NLP) HL and classical HL. Analyses of normal human tissues revealed <jats:italic>BIC<\/jats:italic> transcripts in only a small number of CD20\u2010positive B\u2010cells in lymph node and tonsil tissue, albeit at a much lower level compared to that of RS cells. <jats:italic>BIC<\/jats:italic> RT\u2010PCR in the Burkitt lymphoma\u2013derived cell line Ramos demonstrated a significant up\u2010regulation upon cross\u2010linking of the B\u2010cell receptor (BcR). I\u03baB\u03b1\u2010mediated blocking of NF\u2010\u03baB translocation in Ramos did not effect the up\u2010regulation of <jats:italic>BIC<\/jats:italic> expression upon BcR triggering, suggesting that activation of NF\u2010\u03baB is not involved in regulation of <jats:italic>BIC<\/jats:italic> expression. In summary, our data show that expression of <jats:italic>BIC<\/jats:italic> is specific for RS cells of HL. In normal tissue, <jats:italic>BIC<\/jats:italic> is expressed weakly in a minority of germinal center B cells. Expression of <jats:italic>BIC<\/jats:italic> can be modified\/influenced by BcR triggering, indicating that <jats:italic>BIC<\/jats:italic> might play a role in the selection of B cells. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10186","type":"journal-article","created":{"date-parts":[[2003,3,24]],"date-time":"2003-03-24T11:59:12Z","timestamp":1048507152000},"page":"20-28","source":"Crossref","is-referenced-by-count":199,"title":["High expression of B\u2010cell receptor inducible gene <i>BIC<\/i> in all subtypes of Hodgkin lymphoma"],"prefix":"10.1002","volume":"37","author":[{"given":"Anke","family":"van den 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