{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:29:28Z","timestamp":1791160168598,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,3,18]],"date-time":"2003-03-18T00:00:00Z","timestamp":1047945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pancreatic adenocarcinoma is a disease with high mortality for which chronic pancreatitis confers a markedly increased risk. We hypothesize that chromosome instability and genomic damage occur in pre\u2010neoplastic pancreatic ductal epithelium, and that this damage may be related to oxidative stress. We used dual\u2010color fluorescence in situ hybridization with centromere probes and locus\u2010specific arm probes for chromosome arms 11q, 17p, and 18q to identify genomic instability in cultures of normal\u2010appearing human pancreatic ductal epithelium from normal organ donor controls compared to patients with chronic pancreatitis or pancreatic adenocarcinoma. To examine early pancreatic tumorigenesis, we studied only normal\u2010appearing pancreatic ductal cells adjacent to pancreatitis or carcinoma. We found that, compared to the finding in normal controls, chromosomal abnormalities are present in normal\u2010appearing human pancreatic ductal epithelia obtained from patients with chronic pancreatitis or pancreatic adenocarcinoma. Furthermore, these chromosomal abnormalities could be induced in cultured pancreatic ductal epithelium from normal organ donors by chronic exposure to dilute hydrogen peroxide, suggesting that oxidative stress may contribute to the development of chromosomal instability in the pancreas. These results elucidate a potential mechanism linking chronic pancreatitis to pancreatic cancer and suggest that chromosomal instability may be an early event in the pathogenesis of pancreatic cancer. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10189","type":"journal-article","created":{"date-parts":[[2003,4,10]],"date-time":"2003-04-10T10:01:40Z","timestamp":1049968900000},"page":"201-206","source":"Crossref","is-referenced-by-count":24,"title":["Chromosomal instability in pancreatic ductal cells from patients with chronic pancreatitis and pancreatic adenocarcinoma"],"prefix":"10.1002","volume":"37","author":[{"given":"Alexander H.","family":"Moskovitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J.","family":"Linford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa A.","family":"Brentnall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary P.","family":"Bronner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry E.","family":"Storer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Potter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Richard H.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Rabinovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,3,18]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199903000-00001"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90406-9"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1993.203"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/8816"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2264(2000)9999:9999<::AID-GCC1096>3.0.CO;2-C"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91184-6"},{"key":"e_1_2_3_8_1","first-page":"3568","article-title":"Detection of K\u2010ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia","volume":"54","author":"Caldas C","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.50.1.7"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870090204"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64520-8"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199901000-00012"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1993.tb01550.x"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711680305"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/386623a0"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/25292"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.877619"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(05)70080-7"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-998-0126-6"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng989"},{"key":"e_1_2_3_21_1","first-page":"169","article-title":"CA50 compared with CA19\u20109 as a serum tumor marker for pancreatic carcinoma","volume":"26","author":"Pasquali C","year":"1994","journal-title":"Ital J Gastroenterol"},{"key":"e_1_2_3_22_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF02924191","article-title":"Clinical value of serum TAG\u201072 as a tumor marker for pancreatic carcinoma. 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