{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:14:47Z","timestamp":1790421287941,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,3,17]],"date-time":"2003-03-17T00:00:00Z","timestamp":1047859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytogenetic analysis of a pediatric T\u2010cell acute lymphoblastic leukemia (ALL) cell line (HPB\u2010ALL) revealed the cryptic t(5;14)(q35;q32.2), recently found in 15\u201320% pediatric T\u2010ALL patients, with 5q35 and 14q32.2 breakpoints at 5\u2032\u2010<jats:italic>HOX11L2<\/jats:italic> and 3\u2032\u2010<jats:italic>BCL11B<\/jats:italic>, respectively. Expression of both <jats:italic>BCL11B<\/jats:italic>, which is hematologically restricted to T cells, and <jats:italic>HOX11L2<\/jats:italic> was detected, whereas adjacent genes at 5q35 (<jats:italic>RANBP17<\/jats:italic>) and 14q32 (<jats:italic>VRK1<\/jats:italic>, <jats:italic>HSU88895<\/jats:italic>) were not dysregulated. Apparently, t(5;14)(q35;q32.2) serves to activate <jats:italic>HOX11L2<\/jats:italic> by juxtaposition with elements downstream of <jats:italic>BCL11B<\/jats:italic>, implying a novel dysregulatory mechanism comparable to <jats:italic>TCRA\/D<\/jats:italic> or <jats:italic>IGH<\/jats:italic> juxtaposition. As well as providing molecular cytogenetic documentation of t(5;14) ALL, this report validates HPB\u2010ALL cells for investigating this important new disease entity in vitro. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10194","type":"journal-article","created":{"date-parts":[[2003,3,24]],"date-time":"2003-03-24T11:59:12Z","timestamp":1048507152000},"page":"84-91","source":"Crossref","is-referenced-by-count":49,"title":["Activation of <i>HOX11L2<\/i> by juxtaposition with 3\u2032\u2010<i>BCL11B<\/i> in an acute lymphoblastic leukemia cell line (HPB\u2010ALL) with t(5;14)(q35;q32.2)"],"prefix":"10.1002","volume":"37","author":[{"given":"Roderick A.F.","family":"MacLeod","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Nagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes W.G.","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans G.","family":"Drexler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,3,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-11-0093"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402249"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202078"},{"key":"e_1_2_10_5_1","volume-title":"The leukemia\u2010lymphoma cell line facts book","author":"Drexler HG","year":"2001"},{"key":"e_1_2_10_6_1","volume-title":"Catalogue of human and animal cell lines","author":"Drexler HG","year":"2001"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402799"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00018-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402671"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402347"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3788"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.4.2167"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1099\/0022-1317-78-10-2575","article-title":"Spliced human endogenous retroviral HERV\u2010H env transcripts in T\u2010cell leukaemia cell lines and normal leukocytes: alternative splicing pattern of HERV\u2010H transcripts","volume":"78","author":"Lindeskog M","year":"1997","journal-title":"J Gen Virol"},{"key":"e_1_2_10_14_1","volume-title":"Cancer cell culture\u2014methods and protocols","author":"MacLeod RAF","year":"2003"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(02)00055-3"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910210207"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4938"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.12.3413"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.6.8.1457"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.10194","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.10194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T19:57:56Z","timestamp":1696622276000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.10194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3,17]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,5]]}},"alternative-id":["10.1002\/gcc.10194"],"URL":"https:\/\/doi.org\/10.1002\/gcc.10194","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3,17]]}}}