{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T20:33:09Z","timestamp":1760819589494},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,4,3]],"date-time":"2003-04-03T00:00:00Z","timestamp":1049328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>HLA class I molecules serve the essential immunological function of presenting antigen to CD8+ T lymphocytes. Tumor cells may present tumor\u2010specific antigen to T cells via these molecules, but many tumors show a loss or down\u2010regulation of HLA class I expression and this may serve as an immune escape mechanism. Using a microsatellite marker\u2010based method, we have searched for loss of heterozygosity (LOH) mutations at 3 genomic regions implicated in HLA class I expression in a cohort of 56 acute lymphoblastic leukemia (ALL) samples. The regions analyzed consisted of the HLA class I heavy chain genes located within the MHC genomic region on chromosome arm 6p, the HLA class I light chain (beta\u20102\u2010microglobulin, <jats:italic>B2M<\/jats:italic>) gene on chromosome arm 15q, and the putative HLA modifier of methylation gene (<jats:italic>MEMO1<\/jats:italic>) located on chromosome arm 1q. Results revealed low frequencies of <jats:italic>B2M<\/jats:italic> (2\/55) and <jats:italic>MEMO1<\/jats:italic> (5\/42) LOH but a high frequency of MHC LOH (19\/56) that was usually associated with whole chromosome 6 loss (13\/19). Cytogenetic data were available for 30 samples, including nine of those that exhibited apparent whole chromosome 6 loss. No cases of chromosome 6 monosomy were observed. We propose that whole chromosome 6 loss with reduplication of the remaining chromosome is common in ALL and that it is driven by the presence of tumor\u2010inhibiting factors on chromosome arm 6p (the <jats:italic>HLA<\/jats:italic> loci) along with previously localized tumor\u2010suppressor genes on chromosome arm 6q. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10214","type":"journal-article","created":{"date-parts":[[2003,5,16]],"date-time":"2003-05-16T11:32:50Z","timestamp":1053084770000},"page":"321-325","source":"Crossref","is-referenced-by-count":21,"title":["Evidence for whole chromosome 6 loss and duplication of the remaining chromosome in acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"37","author":[{"given":"Christopher R.E.","family":"McEvoy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander 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