{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:56:34Z","timestamp":1793987794384,"version":"4.8.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,5,20]],"date-time":"2003-05-20T00:00:00Z","timestamp":1053388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Ligue Nationale contre le Cancer (R\u00e9gion Provence Alpes C\u00f4te d'Azur et Corse Comit\u00e9 du Var)"},{"DOI":"10.13039\/100007391","name":"Association pour la Recherche sur le Cancer","doi-asserted-by":"crossref","award":["5955"],"award-info":[{"award-number":["5955"]}],"id":[{"id":"10.13039\/100007391","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Dipl\u00f4me d'Etudes Approfondies Fellowship"},{"name":"Programme Hospitalier de Reserche Clinique regional du CHU de Nice","award":["01-04"],"award-info":[{"award-number":["01-04"]}]},{"DOI":"10.13039\/100008730","name":"Norwegian Cancer Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008730","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005366","name":"University of Oslo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005366","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hibernomas are rare, benign tumors with a histological appearance resembling that of brown adipose tissue. The diagnosis of hibernomas may be difficult because some of them contain only a small number of the characteristic multivacuolated fat cells and can be mistakenly classified as well\u2010differentiated liposarcomas. Cytogenetic information has been reported for 10 cases, showing that these tumors are characterized by structural rearrangements involving 11q13. Previous fluorescence in situ hybridization (FISH) studies revealed consistent and sometimes cryptic losses of the <jats:italic>MEN1<\/jats:italic> region in 11q13.1. Here, we describe the molecular cytogenetic analysis of two new hibernoma cases. Both tumors showed complex rearrangements, simultaneously including translocations, inversions, and deletions affecting the pair of chromosomes 11. The translocation partners were chromosome 5 in one case and chromosomes 16 and 22 in the other case. The 11q13 region was concomitantly rearranged on both chromosomes 11. FISH studies revealed large heterozygous deletions within the 11q13 band, from 11q13.1 to 11q13.5. Genes such as <jats:italic>PYGM<\/jats:italic>, <jats:italic>MEN1<\/jats:italic>, <jats:italic>CCND1<\/jats:italic>, <jats:italic>FGF3<\/jats:italic>, <jats:italic>ARIX<\/jats:italic>, and <jats:italic>GARP<\/jats:italic> were deleted, showing that the size of the 11q13 altered region was larger than previously reported. Furthermore, both tumors had breakpoints in 11q13.5, one of them in the immediate proximity of the <jats:italic>GARP<\/jats:italic> gene. Our results suggest that rearrangements of <jats:italic>GARP<\/jats:italic> or a neighboring gene may be important for the pathogenesis of hibernomas. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10223","type":"journal-article","created":{"date-parts":[[2003,6,6]],"date-time":"2003-06-06T10:07:35Z","timestamp":1054894055000},"page":"389-395","source":"Crossref","is-referenced-by-count":49,"title":["11q13 Alterations in two cases of hibernoma: Large heterozygous deletions and rearrangement breakpoints near <i>GARP<\/i> in 11q13.5"],"prefix":"10.1002","volume":"37","author":[{"given":"Georges","family":"Maire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Forus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Foa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodil","family":"Bjerkehagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Mainguen\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stine H.","family":"Kresse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Myklebost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Pedeutour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,5,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/104454900439773"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000134699"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78617-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1994.1594"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5311.404"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870050212"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.2.115"},{"key":"e_1_2_6_9_1","volume-title":"World Health Organization classification of tumours. 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