{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:02:38Z","timestamp":1791133358046,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,6,9]],"date-time":"2003-06-09T00:00:00Z","timestamp":1055116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The <jats:italic>NUP98<\/jats:italic> gene is involved in several chromosomal abnormalities associated with acute leukemia. The recurrent t(11;20)(p15;q11) chromosomal translocation results in generation of the <jats:italic>NUP98\/TOP1<\/jats:italic> chimeric gene. This abnormality has been observed primarily in therapy\u2010related leukemias, and <jats:italic>TOP1\/NUP98<\/jats:italic> transcripts have not been demonstrated. We describe a case of de novo acute myeloid leukemia with t(11;20)(p15;q11), with no known history of exposure to chemicals. The translocation occurred in intron 13 of <jats:italic>NUP98<\/jats:italic> and intron 7 of <jats:italic>TOP1<\/jats:italic>, as in the three previously reported cases. The breakpoint in <jats:italic>NUP98<\/jats:italic> was exactly the same as that found in a previously reported case. In addition, a reciprocal <jats:italic>TOP1\/NUP98<\/jats:italic> transcript was detected for the first time in our patient. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10239","type":"journal-article","created":{"date-parts":[[2003,7,17]],"date-time":"2003-07-17T10:09:30Z","timestamp":1058436570000},"page":"102-105","source":"Crossref","is-referenced-by-count":12,"title":["Both <i>NUP98\/TOP1<\/i> and <i>TOP1\/NUP98<\/i> transcripts are detected in a de novo AML with t(11;20)(p15;q11)"],"prefix":"10.1002","volume":"38","author":[{"given":"Satsuki","family":"Iwase","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutake","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuaki","family":"Sekikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinobu","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Horiguchi\u2010Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,6,9]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1182\/blood.V94.9.3258","article-title":"The t(11;20)(p15;q11) chromosomal translocation associated with therapy\u2010related myelodysplastic syndrome results in an NUP98\u2010TOP1 fusion","volume":"94","author":"Ahuja HG","year":"1999","journal-title":"Blood"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2264(2000)9999:9999<::AID-GCC1013>3.0.CO;2-T"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007056727876"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0037-1963(00)90017-9"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402269"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10066"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10139"},{"key":"e_1_2_2_9_1","first-page":"4571","article-title":"Novel NUP98\u2010HOXC11 fusion gene related from a chromosomal break within exon 1 of HOXC11 in acute myeloid leukemia with t(11;12)(p15;q13)","volume":"62","author":"Taketani T","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1199"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.10239","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.10239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T12:40:41Z","timestamp":1700224841000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.10239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,9]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["10.1002\/gcc.10239"],"URL":"https:\/\/doi.org\/10.1002\/gcc.10239","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,9]]}}}