{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:00:23Z","timestamp":1773842423677,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,6,19]],"date-time":"2003-06-19T00:00:00Z","timestamp":1055980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chromosomal aberrations were investigated in nuclei extracted from synovial tissue and first\u2010passage synovial fibroblasts (P\u20101 SFB, 98% enrichment) or macrophages (P\u20101 M\u03d5) from patients with rheumatoid arthritis (<jats:italic>n<\/jats:italic> = 10). The findings were compared with those in other rheumatic diseases (osteoarthritis, <jats:italic>n<\/jats:italic> = 14; reactive arthritis, <jats:italic>n<\/jats:italic> = 1), as well as with those in chronic obstructive pulmonary disease (<jats:italic>n<\/jats:italic> = 8). Controls were paired peripheral blood lymphocytes from arthritic patients, synovial tissue or SFB\/M\u03d5 from joint trauma\/normals (<jats:italic>n<\/jats:italic> = 9), and peripheral blood monocytes from normal donors (<jats:italic>n<\/jats:italic> = 10). GTG banding of metaphase chromosomes and interphase fluorescence in situ hybridization with centromere\u2010specific probes were used. Comparable chromosomal aberrations were observed in synovial tissue and P\u20101 SFB of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis (polysomy 7 and aneusomies of chromosomes 4, 8, 9, 12, and 18). Notably, aneusomies of chromosomes 4, 6, 7, 8, 9, 11, 12, and\/or X were also detected in P\u20101 synovial M\u03d5 from rheumatoid arthritis (90% of the cases), osteoarthritis (93%), and reactive arthritis (1\/1), as well as bronchial M\u03d5 from chronic obstructive pulmonary disease (25%). No aberrations were detected in paired peripheral blood lymphocytes (except for one osteoarthritis case with a karyotype 45,X[10]\/46,XX[17]), or in peripheral blood monocytes and synovial tissue of normals\/joint trauma. Because M\u03d5 aberrations were common to chronic joint and pulmonary disease, chronic inflammatory stress may induce chromosomal aberrations with potential functional relevance in local mesenchymal cells and infiltrating leukocytes in an organ\u2010independent fashion. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10242","type":"journal-article","created":{"date-parts":[[2003,7,17]],"date-time":"2003-07-17T10:09:30Z","timestamp":1058436570000},"page":"53-67","source":"Crossref","is-referenced-by-count":18,"title":["Synovial fibroblasts and synovial macrophages from patients with rheumatoid arthritis and other inflammatory joint diseases show chromosomal aberrations"],"prefix":"10.1002","volume":"38","author":[{"given":"Raimund 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