{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:34:29Z","timestamp":1791048869430,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,7,8]],"date-time":"2003-07-08T00:00:00Z","timestamp":1057622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>BIK, a BH (Bcl2 homology domain)3\u2010only protein, is a proapoptotic member of the BCL2 family. We performed single\u2010strand conformational polymorphism and sequencing analysis of the entire coding region of the <jats:italic>BIK<\/jats:italic> gene (exons 2\u20135) in 71 B\u2010cell lymphomas [27 follicular lymphomas (FLs), 13 marginal cell lymphomas (MZLs), 7 small lymphocytic lymphomas (SLLs), 6 mantle cell lymphomas (MCLs), 2 lymphoplasmacytic lymphomas, and 16 diffuse large B\u2010cell lymphomas (DLBCLs)]. Missense <jats:italic>BIK<\/jats:italic> gene mutations were observed in 3 of 27 (11%) FLs, in 2 of 13 (15%) MZLs, and in 1 of 16 (6%) DLBCLs. Sequence alterations in intronic regions were observed in 4 of 27 (14.8%) FLs, in 7 of 13 (53%) MZLs, and in 3 of 16 (18%) DLBCLs. These data indicate that mutation of the <jats:italic>BIK<\/jats:italic> gene is a frequent feature of B\u2010cell lymphomas. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10245","type":"journal-article","created":{"date-parts":[[2003,7,17]],"date-time":"2003-07-17T10:09:30Z","timestamp":1058436570000},"page":"91-96","source":"Crossref","is-referenced-by-count":48,"title":["Mutations of the <i>BIK<\/i> gene in human peripheral B\u2010cell lymphomas"],"prefix":"10.1002","volume":"38","author":[{"given":"Vincenzo","family":"Arena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Martini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Luongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaldo","family":"Capelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi Maria","family":"Larocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,7,8]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400511"},{"key":"e_1_2_3_3_1","first-page":"1921","article-title":"Bik, a novel death\u2010inducing protein shares a distinct sequence motif with Bcl\u20102 family proteins and interacts with viral and cellular survival\u2010promoting proteins","volume":"11","author":"Boyd JM","year":"1995","journal-title":"Oncogene"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70341-0"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.3.1100.415a16_1100_1107"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.39.24494"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201235200"},{"key":"e_1_2_3_8_1","volume-title":"World Health Organization classification of tumours: pathology and genetics of tumours of haematopoietic and lymphoid tissues","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.10.6025"},{"key":"e_1_2_3_10_1","first-page":"1019","article-title":"Bax mutations are an infrequent event in indolent lymphomas and in mantle cell lymphoma","volume":"85","author":"Martini M","year":"2000","journal-title":"Haematologica"},{"key":"e_1_2_3_11_1","first-page":"661","article-title":"Absence of structural mutations of the BAK gene in B cell lymphomas","volume":"87","author":"Martini M","year":"2002","journal-title":"Haematologica"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205340"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2009"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.2.577"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.11.4094"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008983200"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65461-2"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.897601"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.10245","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.10245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T12:40:33Z","timestamp":1700224833000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.10245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7,8]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["10.1002\/gcc.10245"],"URL":"https:\/\/doi.org\/10.1002\/gcc.10245","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,7,8]]}}}