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Today, the Eker rat is one of the best characterized models of tuberous sclerosis complex (TSC) and has been used extensively for study of the function of the <jats:italic>TSC2<\/jats:italic> tumor suppressor gene. Along with <jats:italic>TSC1<\/jats:italic>, these two genes behave as expected for tumor suppressor genes with evidence for loss of heterozygosity in tumors and suppression of growth when expressed in proliferating cells. Despite much experimental work, the mechanisms of these genes have remained elusive until recently. This review summarizes some of the current concepts in our understanding of the biological and biochemical function of the <jats:italic>TSC<\/jats:italic> genes. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10256","type":"journal-article","created":{"date-parts":[[2003,10,15]],"date-time":"2003-10-15T16:54:45Z","timestamp":1066236885000},"page":"368-375","source":"Crossref","is-referenced-by-count":32,"title":["Multiple roles of the tuberous sclerosis complex genes"],"prefix":"10.1002","volume":"38","author":[{"given":"Raymond 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