{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:43:20Z","timestamp":1761057800019},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,10,8]],"date-time":"2003-10-08T00:00:00Z","timestamp":1065571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cancer is a heritable disorder of somatic cells. Environment and heredity both operate in the origin of human cancer. The Eker (<jats:italic>Tsc2<\/jats:italic> gene mutant) rat model of hereditary renal carcinoma (RC) is an example of Mendelian dominantly inherited predisposition to a specific cancer in an experimental animal. To the best of our knowledge, this was the first isolation of a Mendelian dominantly predisposing cancer gene in a naturally occurring animal model. Recently, we discovered a new hereditary renal carcinoma in the rat in Japan, and the rat was named the \u201cNihon\u201d rat, and its predisposing (<jats:italic>Nihon<\/jats:italic>) gene could be a novel renal tumor suppressor gene. We present these unique models, comparing these two predisposing genes (both are located on rat chromosome 10), for the study of problems in carcinogenesis, for instance, species\u2010specific difference in tumorigenesis, cell stage and tissue\/cell\u2010type specific tumorigenesis, multistep carcinogenesis, modifier gene(s) in renal carcinogenesis, cancer prevention, and the development of the therapeutic treatments that can be translated to human patients, as well as how environmental factors interact with cancer susceptibility gene(s). \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10265","type":"journal-article","created":{"date-parts":[[2003,10,15]],"date-time":"2003-10-15T16:54:45Z","timestamp":1066236885000},"page":"357-367","source":"Crossref","is-referenced-by-count":9,"title":["Hereditary renal carcinogenesis fitting Knudson's two\u2010hit model: Genotype, environment, and phenotype"],"prefix":"10.1002","volume":"38","author":[{"given":"Okio","family":"Hino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,10,8]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0776"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/189858b0"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37087-8"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1998.tb00503.x"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb847"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.2.730"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.1.327"},{"key":"e_1_2_17_9_1","first-page":"5856","article-title":"Genetic predisposition to transplacentally induced renal cell carcinomas in the Eker 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