{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:49:25Z","timestamp":1792032565143,"version":"4.4.0"},"reference-count":103,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,10,8]],"date-time":"2003-10-08T00:00:00Z","timestamp":1065571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neurofibromatosis type II (NF2) is an autosomal dominant cancer syndrome characterized by the formation of tumors of the nervous system, particularly schwannomas and meningiomas. The<jats:italic>NF2<\/jats:italic>gene is also implicated in the development of sporadic schwannomas and meningiomas, as well as tumor types seemingly unrelated to the NF2 disorder, such as malignant mesotheliomas. Inactivation of<jats:italic>NF2<\/jats:italic>occurs by a \u201ctwo\u2010hit\u201d mechanism, as proposed by Al Knudson, and the<jats:italic>NF2<\/jats:italic>gene behaves as a classical tumor suppressor gene. The<jats:italic>NF2<\/jats:italic>gene product, merlin, exhibits homology with the ezrin\u2013radixin\u2013moesin family of membrane\u2013cytoskeleton\u2010linking proteins. During the past several years, there has been intensive investigation aimed at elucidating the mechanisms underlying merlin's functions. In this review, we summarize the involvement of<jats:italic>NF2<\/jats:italic>inactivation in tumorigenesis. We also discuss observations implicating merlin in cell motility and cell proliferation, with a focus on recent findings linking merlin to Rac signaling. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.10282","type":"journal-article","created":{"date-parts":[[2003,10,15]],"date-time":"2003-10-15T16:54:45Z","timestamp":1066236885000},"page":"389-399","source":"Crossref","is-referenced-by-count":64,"title":["<i>NF2<\/i>: The wizardry of merlin"],"prefix":"10.1002","volume":"38","author":[{"given":"Guang\u2010Hui","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Chernoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph 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