{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:52:42Z","timestamp":1781653962841,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,4,30]],"date-time":"2001-04-30T00:00:00Z","timestamp":988588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>T\u2010cell prolymphocytic leukemia (T\u2010PLL) is a rare malignant proliferation of lymphoid cells with a postthymic phenotype. Previous cytogenetic and molecular studies reported complex karyotypes with recurrent chromosomal abnormalities, including translocations involving either <jats:italic>TCL1<\/jats:italic> at 14q32.1 or <jats:italic>MTCP1<\/jats:italic> at Xq28, inactivation of the <jats:italic>ATM<\/jats:italic> gene by deletion and\/or mutation, and isochromosomes 8. For extensive study of chromosomal imbalances in T\u2010PLL, we analyzed 22 tumoral DNAs using comparative genomic hybridization (CGH). Abnormal CGH profiles were detected in all cases, demonstrating highly recurrent gains and losses and largely extending the abnormalities previously established. Only a few nonrecurrent abnormalities were observed, in contrast to the genetic instability anticipated from <jats:italic>ATM<\/jats:italic> inactivation. Nine recurrent regions of loss were identified at 8p (frequency 86%), 11q (68%), 22q11 (45%), 13q (41%), 6q (36%), 9p (27%), 12p (23%), 11p11\u2013p14 (23%), and 17p (23%), as well as four regions of gain at 8q (82%), 14q32 (50%), 22q21\u2013qter (41%), and 6p (23%). Several recurrent chromosomal abnormalities were simultaneously present in each case (mean, 5.7; up to 10), none being mutually exclusive of another. Fluorescence in situ hybridization analysis confirmed and extended 22q11 and 13q losses, giving final frequencies of 55% and 45%, respectively. Analysis of one case over a 7\u2010year period confirmed the overall genetic stability of T\u2010PLL and showed that tumor progression was associated with the onset of a few chromosomal abnormalities. This study establishes a complex pattern of highly recurrent chromosomal abnormalities in T\u2010PLL, including some, such as chromosome 13 deletion, commonly found in other lymphoid malignancies. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.1141","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T20:37:10Z","timestamp":1030307830000},"page":"248-254","source":"Crossref","is-referenced-by-count":76,"title":["A complex pattern of recurrent chromosomal losses and gains in T\u2010cell prolymphocytic leukemia"],"prefix":"10.1002","volume":"31","author":[{"given":"Jean","family":"Soulier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Pierron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Vecchione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Garand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Brizard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Sigaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc\u2010Henri","family":"Stern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Aurias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,4,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(98)00286-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100380050178"},{"key":"e_1_2_6_4_1","first-page":"4365","article-title":"Increased number of chromosomal imbalances and high\u2010level DNA amplifications in mantle cell lymphoma are associated with blastoid variants","volume":"93","author":"Bea S","year":"1999","journal-title":"Blood"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1182\/blood.V85.12.3610.bloodjournal85123610","article-title":"Comparative genomic hybridization in chronic B\u2010cell leukemias shows a high incidence of chromosomal gains and losses","volume":"85","author":"Bentz M","year":"1995","journal-title":"Blood"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V70.4.926.926"},{"key":"e_1_2_6_7_1","first-page":"24","article-title":"ATM mutations in B\u2010cell chronic lymphocytic leukemia","volume":"59","author":"Bullrich F","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1182\/blood.V91.8.3007.3007_3007_3010","article-title":"Characterization of nonrandom chromosomal gains and losses in multiple myeloma by comparative genomic hybridization","volume":"91","author":"Cigudosa JC","year":"1998","journal-title":"Blood"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1182\/blood.V91.4.1382","article-title":"Detailed molecular delineation of 13q14.3 loss in B\u2010cell chronic lymphocytic leukemia","volume":"91","author":"Corcoran MM","year":"1998","journal-title":"Blood"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203283"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.990190105"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00977.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(94)90042-6"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200008"},{"key":"e_1_2_6_15_1","first-page":"787","article-title":"Inverted duplication of JH associated with chromosome 14 translocation and T\u2010cell leukemia in ataxia\u2010telangiectasia","volume":"39","author":"Johnson JP","year":"1986","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.6.2156"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870100403"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401644"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.10.1246"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1182\/blood.V86.5.1911.bloodjournal8651911","article-title":"13q deletions in lymphoid malignancies","volume":"86","author":"Liu Y","year":"1995","journal-title":"Blood"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(97)00410-X"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.12.3269.3269"},{"key":"e_1_2_6_23_1","volume-title":"Catalog of chromosome aberrations in cancer '98","author":"Mitelman F","year":"1998"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb04829.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.6.2949"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.12.6664"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199911)26:3<210::AID-GCC4>3.0.CO;2-J"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401034"},{"key":"e_1_2_6_29_1","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1182\/blood.V94.2.748","article-title":"Somatic ATM mutations indicate a pathogenic role of ATM in B\u2010cell chronic lymphocytic leukemia","volume":"94","author":"Schaffner C","year":"1999","journal-title":"Blood"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.050400997"},{"key":"e_1_2_6_31_1","first-page":"3114","article-title":"Clinicopathogenetic significance of chromosomal abnormalities in patients with blastic peripheral B\u2010cell lymphoma: Kiel\u2010Wien\u2010Lymphoma Study Group","volume":"94","author":"Schlegelberger B","year":"1999","journal-title":"Blood"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00283722"},{"key":"e_1_2_6_33_1","first-page":"2475","article-title":"MTCP\u20101: a novel gene on the human chromosome Xq28 translocated to the T\u2010cell receptor alpha\/delta locus in mature T\u2010cell proliferations","volume":"8","author":"Stern MH","year":"1993","journal-title":"Oncogene"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1097-1155"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.10.3920.3920_3920_3926"},{"key":"e_1_2_6_36_1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1182\/blood.V96.1.374a","article-title":"No germline ATM mutation in a series of 16 in T\u2010cell prolymphocytic leukemias","volume":"96","author":"Stoppa\u2010Lyonnet D","year":"2000","journal-title":"Blood"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.2.423.bloodjournal872423"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.26.12530"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0997-96"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201603"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.1141","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.1141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T15:39:12Z","timestamp":1700321952000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.1141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4,30]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,7]]}},"alternative-id":["10.1002\/gcc.1141"],"URL":"https:\/\/doi.org\/10.1002\/gcc.1141","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4,30]]}}}