{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:27:22Z","timestamp":1789964842860,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,6,7]],"date-time":"2001-06-07T00:00:00Z","timestamp":991872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"crossref","award":["70-2310-Ba"],"award-info":[{"award-number":["70-2310-Ba"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"crossref","award":["10-1556-Schl4"],"award-info":[{"award-number":["10-1556-Schl4"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Wilhem Sander Stiftung","award":["98.086.1"],"award-info":[{"award-number":["98.086.1"]}]},{"name":"Medical Faculty of the University of Ulm","award":["P389"],"award-info":[{"award-number":["P389"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Extranodal B\u2010cell lymphoma of mucosa\u2010associated lymphoid tissue (MALT) type may represent a model of lymphoma progression, because a small cell component frequently occurs in the large cell variants. We studied 52 extranodal B\u2010cell lymphomas: 18 extranodal marginal zone B\u2010cell lymphomas of MALT type (MZBL,MT), 7 MZBL,MT of the gastro\u2010intestinal tract with a diffuse large B\u2010cell component (giMZBL\n                    <jats:italic>plus<\/jats:italic>\n                    LBCL), and 27 diffuse large B\u2010cell lymphomas of the gastro\u2010intestinal tract without small cell component (giLBCL). Analytical techniques were comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH). The translocation t(11;18) was found as the sole aberration in two MZBL,MT only. In contrast to this, t(11;18)\u2010negative MZBL,MT were characterized by frequent gains on chromosome 3 and DNA amplifications on 2p13\u2013p15. Furthermore, we found a clonal lymphoma progression from the small to the large cell component with accumulation of gains and losses of chromosomal material in the large cell component in giMZBL\n                    <jats:italic>plus<\/jats:italic>\n                    LBCL. Aberrations overlapping with MZBL,MT and giMZBL\n                    <jats:italic>plus<\/jats:italic>\n                    LBCL included losses on chromosome 13, amplifications of the\n                    <jats:italic>REL<\/jats:italic>\n                    proto\u2010oncogene, or gains on chromosome 12. In addition, the large cell component revealed gains on 8q24, including amplifications of the\n                    <jats:italic>MYC<\/jats:italic>\n                    proto\u2010oncogene, and losses on 2q. The giLBCL had frequent gains on chromosomes 12 and 9, as well as on 11q, and losses on 6q. We conclude that, based on the distinctive and partly overlapping patterns of genetic aberrations, MALT lymphomas can be divided into different genetic subgroups. \u00a9 2001 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/gcc.1150","type":"journal-article","created":{"date-parts":[[2002,9,10]],"date-time":"2002-09-10T21:23:48Z","timestamp":1031693028000},"page":"316-325","source":"Crossref","is-referenced-by-count":77,"title":["Molecular\u2010cytogenetic comparison of mucosa\u2010associated marginal zone B\u2010cell lymphoma and large B\u2010cell lymphoma arising in the gastro\u2010intestinal tract"],"prefix":"10.1002","volume":"31","author":[{"given":"Thomas F.E.","family":"Barth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bentz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Leith\u00e4user","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Stilgenbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Siebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Schlotter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard 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