{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:32:52Z","timestamp":1774949572880,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,6,7]],"date-time":"2001-06-07T00:00:00Z","timestamp":991872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Association pour la Recherche en Canc\u00e9rologie"},{"name":"Ligue Nationale contre le Cancer (Comit\u00e9s de la Vienne et Charente-Maritime)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mixed lineage leukemia, <jats:italic>MLL<\/jats:italic>, gene is frequently rearranged in patients with secondary leukemia following treatment with DNA topoisomerase II inhibitors. By FISH and Southern blot analyses we identified a rearrangement in the <jats:italic>MLL<\/jats:italic> gene due to a novel t(3;11)(q28;q23) chromosomal translocation in a patient who developed AML\u2010M5 3 years after treatment for a follicular lymphoma. Through inverse PCR, the <jats:italic>LPP<\/jats:italic> (lipoma preferred partner) gene on 3q28 was identified as the <jats:italic>MLL<\/jats:italic> fusion partner. LPP contains substantial identity to the focal adhesion protein, zyxin, and is frequently fused to <jats:italic>HMGIC<\/jats:italic> in lipomas. The breakpoint occurred in intron 8 of <jats:italic>MLL<\/jats:italic> and <jats:italic>LPP<\/jats:italic>. Two in\u2010frame <jats:italic>MLL\u2010LPP<\/jats:italic> transcripts, which fuse <jats:italic>MLL<\/jats:italic> exon 8 to <jats:italic>LPP<\/jats:italic> exon 9, were detected by RT\u2010PCR, although the smaller of these contained a deletion of 120 bp from the <jats:italic>MLL<\/jats:italic> sequence. The predicted MLL\u2010LPP fusion protein includes the A\/T hook motifs and methyltransferase domain of MLL joined to the two last LIM domains of LPP. A reciprocal <jats:italic>LPP\u2010MLL<\/jats:italic> transcript, predicted to include the proline\u2010rich and leucine zipper motifs, and the first LIM domain of LPP were also detected by RT\u2010PCR. In summary, <jats:italic>LPP<\/jats:italic> is a newly identified <jats:italic>MLL<\/jats:italic> fusion partner in secondary leukemia resulting from topoisomerase inhibitors. The MLL\u2010LPP and LPP\u2010MLL predicted proteins contain many of the features present in other <jats:italic>MLL<\/jats:italic> rearrangements. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.1157","type":"journal-article","created":{"date-parts":[[2002,9,11]],"date-time":"2002-09-11T01:23:48Z","timestamp":1031707428000},"page":"382-389","source":"Crossref","is-referenced-by-count":45,"title":["Human <i>LPP<\/i> gene is fused to <i>MLL<\/i> in a secondary acute leukemia with a t(3;11) (q28;q23)"],"prefix":"10.1002","volume":"31","author":[{"given":"Laurence","family":"Dah\u00e9ron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Veinstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Brizard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Drabkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Lacotte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Guilhot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian 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