{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:08:38Z","timestamp":1791227318535,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,7,3]],"date-time":"2001-07-03T00:00:00Z","timestamp":994118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"crossref","award":["10-1243 Bo"],"award-info":[{"award-number":["10-1243 Bo"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010142","name":"\u00d6sterreichische Kinderkrebshilfe","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010142","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The <jats:italic>MLL<\/jats:italic> (<jats:italic>HRX, ALL\u20101 HTRX<\/jats:italic>) gene at chromosome band 11q23 frequently is rearranged in acute lymphoblastic and myeloblastic leukemia. To date, more than 40 different 11q23 abnormalities have been described on the cytogenetic level, and at least 25 of the respective fusion partner genes are cloned. The vast majority of the respective reciprocal translocations generate a chimeric 5\u2032\u2010<jats:italic>MLL<\/jats:italic>\/partner\u20103\u2032 gene on the derivative 11q23. In this work, we report a unique ins(X;11)(q24;q23) in an infant with acute myeloid leukemia (AML\u2010M2) that fuses the human <jats:italic>KIAA0128<\/jats:italic> gene at Xq24 with <jats:italic>MLL<\/jats:italic>. In contrast to the typical reciprocal <jats:italic>MLL<\/jats:italic> translocations, however, we provide evidence that the 5\u2032\u2010<jats:italic>MLL\/KIAA0128<\/jats:italic>\u20103\u2032 fusion resides on Xq24 rather than on 11q23. The <jats:italic>KIAA0128<\/jats:italic> gene encodes the human Septin 6 protein, which contains an ATP\u2010GTP binding motif and three nuclear targeting sequences in its carboxy terminus. The maintenance of the reading frame of the 5\u2032\u2010<jats:italic>MLL\/KIAA0128<\/jats:italic>\u20103\u2032 mRNA fusion allows for the formation of a novel chimeric protein. Septin 6 is the third member of the Septins that is fused to the MLL protein; the other two are hCDCrel at 22q11 and MSF at 17q25. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.1169","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:50:36Z","timestamp":1030312236000},"page":"82-88","source":"Crossref","is-referenced-by-count":54,"title":["An ins(X;11)(q24;q23) fuses the <i>MLL<\/i> and the <i>Septin 6\/KIAA0128<\/i> gene in an infant with AML\u2010M2"],"prefix":"10.1002","volume":"32","author":[{"given":"Arndt","family":"Borkhardt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Teigler\u2010Schlegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Harbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar A.","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,7,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.7.2870.bloodjournal8772870"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/8100"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870130202"},{"key":"e_1_2_5_5_1","first-page":"549","article-title":"Molecular analysis of MLL\u20101\/AF4 recombination in infant acute lymphoblastic leukemia","volume":"8","author":"Borkhardt A","year":"1994","journal-title":"Leukemia"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1200814"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199808240-00042"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.18.8538"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81269-6"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0498-331"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01439.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.5.843"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.6.12.1843"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(99)01632-3"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.122.2.373"},{"key":"e_1_2_5_16_1","first-page":"95","article-title":"Molecular abnormalities in leukemia: the 11q23 story so far","volume":"12","author":"Gregorini A","year":"1998","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90603-A"},{"key":"e_1_2_5_18_1","first-page":"2327","article-title":"Sequence analysis of the breakpoint cluster region in the ALL\u2010 1 gene involved in acute leukemia","volume":"54","author":"Gu Y","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401018"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401017"},{"key":"e_1_2_5_21_1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/sj.leu.2401413","article-title":"Cytogenetic studies of infant acute lymphoblastic leukemia: poor prognosis of infants with t(4;11)\u2014a report of the Children's Cancer Group","volume":"13","author":"Heerema NA","year":"1999","journal-title":"Leukemia"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(99)00250-2"},{"key":"e_1_2_5_23_1","first-page":"103","article-title":"The molecular pathogenesis of treatment\u2010induced (secondary) leukemias: Foundations for treatment and prevention","volume":"24","author":"Karp JE","year":"1997","journal-title":"Semin Oncol"},{"key":"e_1_2_5_24_1","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1182\/blood.V80.7.1659.1659","article-title":"Chromosome 11q23 translocations in both infant and adult acute leukemias are detected by in situ hybridization with a yeast artificial chromosome","volume":"80","author":"Kearney L","year":"1992","journal-title":"Blood"},{"key":"e_1_2_5_25_1","first-page":"708","article-title":"Phenotypic and genotypic heterogeneity in infant acute leukemia. II. Acute nonlymphoblastic leukemia","volume":"3","author":"K\u00f6ller U","year":"1989","journal-title":"Leukemia"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.14.4226"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.190167297"},{"key":"e_1_2_5_28_1","first-page":"1299","article-title":"Detection of 11q23\/MLL rearrangements in infant leukemias with fluorescence in situ hybridization and molecular analysis","volume":"9","author":"Martinez\u2010Climent JA","year":"1995","journal-title":"Leukemia"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6413"},{"key":"e_1_2_5_30_1","unstructured":"MitelmanF JohanssonB MertensF.2001. Mitelman database of chromosome aberrations in cancer.http:\/\/cgap.nci.nih.gov\/Chromosomes\/Mitelman."},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(98)00131-3"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90152-X"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.11.6428"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870110203"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.2.438"},{"key":"e_1_2_5_36_1","first-page":"952","article-title":"Prognostic factors in the acute lymphoid and myeloid leukemias of infants","volume":"10","author":"Pui CH","year":"1996","journal-title":"Leukemia"},{"key":"e_1_2_5_37_1","first-page":"59","article-title":"The role of chromosome translocations in leukemogenesis","volume":"36","author":"Rowley JD","year":"1999","journal-title":"Semin Hematol"},{"key":"e_1_2_5_38_1","first-page":"74","article-title":"11q23 rearrangements in acute leukemia","volume":"10","author":"Rubnitz J","year":"1996","journal-title":"Leukemia"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401011"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.2.569"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90602-9"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(200005)28:1<14::AID-GCC2>3.0.CO;2-X"},{"key":"e_1_2_5_43_1","first-page":"225","article-title":"Chromosome abnormalities in leukaemia: the 11q23 paradigm","volume":"28","author":"Young BD","year":"1996","journal-title":"Cancer Surv"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.00399.x"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.23.10735"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.1169","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.1169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T13:21:39Z","timestamp":1697462499000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.1169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7,23]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["10.1002\/gcc.1169"],"URL":"https:\/\/doi.org\/10.1002\/gcc.1169","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7,23]]}}}