{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:17:38Z","timestamp":1790212658903,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,8,3]],"date-time":"2001-08-03T00:00:00Z","timestamp":996796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Benign mesenchymal neoplasms associated with rearrangements of the DNA architectural factor gene <jats:italic>HMGIC<\/jats:italic> on chromosome 12 include lipomas, uterine leiomyomata, pulmonary chondroid hamartomas, endometrial polyps, salivary gland pleomorphic adenomas, and breast fibroadenomas. Although <jats:italic>HMGIC<\/jats:italic> also has been implicated in the pathobiology of aggressive angiomyxoma of the vulva, the molecular mechanisms pertaining to this neoplasm are unclear. Tissue from a recurrent aggressive angiomyxoma was investigated by cytogenetic and expression analysis for <jats:italic>HMGIC<\/jats:italic> and <jats:italic>HMGIY<\/jats:italic>. The trypsin\u2010Giemsa\u2010banded karyotype showed a clonal translocation between chromosomes 8 and 12 [46,XX,t(8;12)(p12;q15)]. Fluorescence in situ hybridization (FISH) analysis with whole chromosome paint probes for chromosomes 8 and 12 excluded cryptic involvement of other chromosomes. The chromosome 12 breakpoint was mapped with two\u2010color FISH analysis using cosmid probes at the 5\u2032 and 3\u2032 termini of <jats:italic>HMGIC<\/jats:italic>. Both cosmid probes showed hybridization to the normal chromosome 12 and the der(12) chromosome, indicating that the breakpoint was 3\u2032 (telomeric) to the gene. Reverse transcriptase\u2010polymerase chain reaction (RT\u2010PCR) analysis revealed <jats:italic>HMGIC<\/jats:italic> expression in the tumor, and immunohistochemistry localized <jats:italic>HMGIC<\/jats:italic> expression to the tumor's spindle cells. Like numerous benign mesenchymal tumors, this locally aggressive tumor is associated with rearrangements near or within <jats:italic>HMGIC<\/jats:italic>, but chimeric gene formation was not required for tumorigenesis. Inappropriate expression of this DNA binding protein, however, may be important in the pathobiology of this tumor. Understanding the pathogenetic mechanism may also be helpful in developing new diagnostic tools for identifying residual disease. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.1179","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T19:56:46Z","timestamp":1030305406000},"page":"172-176","source":"Crossref","is-referenced-by-count":100,"title":["Chromosomal translocation t(8;12) induces aberrant <i>HMGIC<\/i> expression in aggressive angiomyxoma of the vulva"],"prefix":"10.1002","volume":"32","author":[{"given":"Marisa R.","family":"Nucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislawa","family":"Weremowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Neskey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris","family":"Sornberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Tallini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia C.","family":"Morton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Quade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,8,3]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90052-7"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(96)85316-7"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/23.21.4262"},{"key":"e_1_2_2_5_1","first-page":"1307","article-title":"The expression of the high mobility group HMGI (Y) proteins correlates with the malignant phenotype of human thyroid neoplasias","volume":"10","author":"Chiappetta G","year":"1995","journal-title":"Oncogene"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870080211"},{"key":"e_1_2_2_7_1","first-page":"2278","article-title":"Genomic changes in endometrial polyps associated with tamoxifen show no evidence for its action as an external carcinogen","volume":"58","author":"Dal Cin P","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960701)78:1<79::AID-CNCR13>3.0.CO;2-4"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199908)25:4<316::AID-GCC2>3.0.CO;2-0"},{"key":"e_1_2_2_10_1","first-page":"13","article-title":"Expression of reciprocal hybrid transcripts of HMGIC and FHIT in a pleomorphic adenoma of the parotid gland","volume":"57","author":"Geurts JM","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(91)90436-X"},{"key":"e_1_2_2_12_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/ajcp\/104.4.391","article-title":"Aggressive angiomyxoma in males. 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