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The latter is thought to reflect a persistent preleukemic stage and a requirement for secondary genetic events. We sought to examine this further by examination of blood spots in rare cases of <jats:italic>MLL<\/jats:italic> fusion\u2010positive or <jats:italic>ETV6\/RUNX1<\/jats:italic> (<jats:italic>TEL\u2010AML1<\/jats:italic>) fusion gene\u2013positive acute leukemia that were diagnosed at ages beyond the normal age range. We present evidence that the duration of the postnatal preleukemic state can occasionally be very protracted in these biological subtypes of pediatric leukemia, and we discuss its biological significance. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20003","type":"journal-article","created":{"date-parts":[[2004,2,18]],"date-time":"2004-02-18T10:00:27Z","timestamp":1077098427000},"page":"335-340","source":"Crossref","is-referenced-by-count":57,"title":["Protracted postnatal natural histories in childhood leukemia"],"prefix":"10.1002","volume":"39","author":[{"given":"Ana 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