{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:26:37Z","timestamp":1791973597086,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,5,19]],"date-time":"2004-05-19T00:00:00Z","timestamp":1084924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chordomas are rare sacrococcygeal\/sacral, sphenooccipital\/clivus, and spinal tumors whose molecular etiology remains relatively understudied. As several anecdotal reports had described chordomas in individuals with tuberous sclerosis complex (TSC), a multisystem hamartoma syndrome, we hypothesized that the genes that cause TSC may have an etiological role in chordomas. In two cases of sacrococcygeal chordomas in individuals with TSC, one with a germ\u2010line <jats:italic>TSC2<\/jats:italic> mutation and the other with a germ\u2010line <jats:italic>TSC1<\/jats:italic> mutation, we confirmed somatic inactivation of the corresponding wild\u2010type allele by loss of heterozygosity analysis and immunohistochemistry. These data provide the first evidence of a pathogenic role by TSC genes in sacrococcygeal chordomas. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20052","type":"journal-article","created":{"date-parts":[[2004,5,19]],"date-time":"2004-05-19T15:01:08Z","timestamp":1084978868000},"page":"80-85","source":"Crossref","is-referenced-by-count":55,"title":["Sacrococcygeal chordomas in patients with tuberous sclerosis complex show somatic loss of <i>TSC1<\/i> or <i>TSC2<\/i>"],"prefix":"10.1002","volume":"41","author":[{"given":"Lisa","family":"Lee\u2010Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Aligianis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter 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