{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:06:19Z","timestamp":1783051579884,"version":"3.54.6"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,6,10]],"date-time":"2004-06-10T00:00:00Z","timestamp":1086825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increased transcriptional activity of the <jats:italic>MYC<\/jats:italic> gene is a characteristic feature of Burkitt's lymphoma. Aberrant <jats:italic>MYC<\/jats:italic> expression is caused by (1) chromosomal translocation to one of the loci carrying an immunoglobulin gene, (2) mutation within the translocated allele, (3) loss of the block to transcription elongation, or (4) promoter shift. To investigate the influence of breakpoint locations within the <jats:italic>MYC<\/jats:italic> gene on <jats:italic>MYC<\/jats:italic> transcript levels, we determined both the precise genomic <jats:italic>MYC\/IGH<\/jats:italic> breakpoints and the amount of <jats:italic>MYC<\/jats:italic> mRNA in 25 samples of pediatric Burkitt's lymphoma with translocation t(8;14)(q24;q32). Patients with breakpoints that were 5\u2032 from <jats:italic>MYC<\/jats:italic> exon 1 had significantly lower expression of <jats:italic>MYC<\/jats:italic> than did patients who had a breakpoint within exon 1 or intron 1 (<jats:italic>P<\/jats:italic> &lt; 0.05 and 0.005, respectively). The highest mRNA level of <jats:italic>MYC<\/jats:italic> (1,006 copies per 100 copies <jats:italic>ABL<\/jats:italic>1) was detected in patients with loss of the first exon and transcription initiation from a cryptic P3 promoter within the first intron of the <jats:italic>MYC<\/jats:italic> gene. In contrast, there was no obvious correlation between breakpoint locations within the <jats:italic>IgH<\/jats:italic> locus and the amount of <jats:italic>MYC<\/jats:italic> mRNA. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20063","type":"journal-article","created":{"date-parts":[[2004,6,10]],"date-time":"2004-06-10T20:03:04Z","timestamp":1086897784000},"page":"178-182","source":"Crossref","is-referenced-by-count":39,"title":["Level of <i>MYC<\/i> overexpression in pediatric Burkitt's lymphoma is strongly dependent on genomic breakpoint location within the <i>MYC<\/i> locus"],"prefix":"10.1002","volume":"41","author":[{"given":"Monika","family":"Wilda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Busch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irmgard","family":"Klose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Woessmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Kreuder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Harbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt","family":"Borkhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,6,10]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3685977"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7824"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1.7.659"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.21.3707"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.12.11.5206"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.18.2212"},{"key":"e_1_2_3_8_1","first-page":"5625","article-title":"B\u2010cell tumorigenesis in mice carrying a yeast artificial chromosome\u2010based immunoglobulin heavy\/c\u2010myc translocus is independent of the heavy chain intron enhancer (Emu)","volume":"59","author":"Palomo C","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_3_9_1","first-page":"283","article-title":"Regulation of c\u2010myc transcription initiation and elongation","volume":"3","author":"Snyder RC","year":"1992","journal-title":"Crit Rev Oncogenet"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.4.1.75"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7837"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90227-7"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403254"},{"key":"e_1_2_3_14_1","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.1016\/S0021-9258(19)39597-3","article-title":"Phosphorylation\u2010dependent binding of a 138\u2010kDa myc intron factor to a regulatory element in the first intron of the c\u2010myc gene","volume":"15","author":"Zajac\u2010Kaye M","year":"1990","journal-title":"J Biol Chem"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2454510"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.20063","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.20063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:23:02Z","timestamp":1700180582000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.20063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,10]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["10.1002\/gcc.20063"],"URL":"https:\/\/doi.org\/10.1002\/gcc.20063","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6,10]]}}}