{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:42:06Z","timestamp":1775576526524,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,8,11]],"date-time":"2004-08-11T00:00:00Z","timestamp":1092182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swedish Cancer Society"},{"name":"Medical Faculty of Lund University, Sweden"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) are characterized cytogenetically by 14q32 rearrangements, \u221213\/13q\u2212, and various trisomies. Occasionally, karyotypic patterns characteristic of myelodysplastic syndrome (MDS)\/acute myeloid leukemia (AML) occur in MM, often signifying therapy\u2010related (t)\u2010MDS\/t\u2010AML. Comparison of cytogenetic features in all published MMs (<jats:italic>n<\/jats:italic> = 993) and t\u2010MDS\/t\u2010AML post\u2010MM (<jats:italic>n<\/jats:italic> = 117) revealed significant differences in complexity and ploidy levels and in most genomic changes. Thus, these features often can be used to distinguish between MM and t\u2010MDS\/t\u2010AML. Rarely, myeloid\u2010associated aberrations are detected in MM without any signs of MDS\/AML. To characterize such abnormalities in MM\/MGUS, we ascertained all 122 MM and 26 MGUS\/smoldering MM (SMM) cases analyzed in our department. Sixty\u2010six (54%) MMs and 8 (31%) MGUS\/SMMs were karyotypically abnormal, of which 6 (9%) MMs and 3 (38%) MGUS\/SMMs displayed myeloid abnormalities, that is, +8 (1 case) and 20q\u2212 (8 cases) as the sole anomalies, without any evidence of MDS\/AML. One patient developed AML, whereas no MDS\/AML occurred in the remaining 8 patients. In one MGUS with del(20q), fluorescence in situ hybridization analyses revealed its presence in CD34+CD38\u2212 (hematopoietic stem cells), CD34+CD38+ (progenitors), CD19+ (B cells), and CD15+ (myeloid cells). The present data indicate that 20q\u2212 occurs in 10% of karyotypically abnormal MM\/MGUS cases and that it might arise at a multipotent progenitor\/stem cell level. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20078","type":"journal-article","created":{"date-parts":[[2004,8,11]],"date-time":"2004-08-11T18:06:13Z","timestamp":1092247573000},"page":"223-231","source":"Crossref","is-referenced-by-count":24,"title":["MDS\/AML\u2010associated cytogenetic abnormalities in multiple myeloma and monoclonal gammopathy of undetermined significance: Evidence for frequent de novo occurrence and multipotent stem cell involvement of del(20q)"],"prefix":"10.1002","volume":"41","author":[{"given":"Therese","family":"Nilsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stig","family":"Lenhoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Rylander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingbritt","family":"\u00c5strand\u2010Grundstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bodil","family":"Str\u00f6mbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattias","family":"H\u00f6glund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingemar","family":"Turesson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Westin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Mitelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sten E. 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