{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T08:34:22Z","timestamp":1722933262478},"reference-count":61,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,9,21]],"date-time":"2004-09-21T00:00:00Z","timestamp":1095724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>HOX11<\/jats:italic> is a homeobox gene originally identified at a chromosomal breakpoint in T\u2010cell acute lymphoblastic leukemia (T\u2010ALL). It is one of the most frequently deregulated genes in T\u2010ALL, although the precise role of <jats:italic>HOX11<\/jats:italic> in leukemogenesis as well as in normal development remains obscure. To gain more insight into the functional role of <jats:italic>HOX11<\/jats:italic>, we utilized a microarray model system to characterize the gene expression network that it directs. Using one of our T\u2010ALL cell lines that had been stably transfected to express <jats:italic>HOX11<\/jats:italic> and high\u2010density oligonucleotide HG\u2010U95A arrays, we identified a large number of differentially expressed genes in response to the enforced expression of <jats:italic>HOX11<\/jats:italic>. We focused on examining genes found to be up\u2010regulated according to the microarray analysis and selected three putative target genes, <jats:italic>NFKB2, SMARCD3<\/jats:italic>, and <jats:italic>NR4A3<\/jats:italic>, for further investigation. We could not only confirm the up\u2010regulation of <jats:italic>NR4A3<\/jats:italic> by an independent method in all clones expressing <jats:italic>HOX11<\/jats:italic>, but luciferase reporter assays demonstrated that the effect that HOX11 exerted on the proximal promoter of <jats:italic>NR4A3<\/jats:italic> was dependent on the presence of an intact homeodomain, providing support for the idea that HOX11 manifests its regulatory function via its action as a transcription factor. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20104","type":"journal-article","created":{"date-parts":[[2004,9,21]],"date-time":"2004-09-21T21:00:25Z","timestamp":1095800425000},"page":"309-320","source":"Crossref","is-referenced-by-count":17,"title":["A microarray model system identifies potential new target genes of the proto\u2010oncogene 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