{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:26:51Z","timestamp":1791487611559,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,11,11]],"date-time":"2004-11-11T00:00:00Z","timestamp":1100131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous cytogenetic studies in mycosis fungoides (MF) and Sezary syndrome (SS) have identified a large and poorly defined area of chromosomal deletion on chromosome 10q. We report an extensive fine\u2010mapping allelotyping study using 19 microsatellite markers in the region 10q22.3\u201310q26.13. Allelic loss was identified by loss of heterozygosity analysis in 26 of 60 (43%) cases: 15 of 45 (33%) with MF and 11 of 15 (73%) with SS. MF and SS samples showed similar patterns of allelic loss with the identification of two discrete regions of deletion which were mutually exclusive in all but two cases. Within the first region of deletion at 10q23.33\u201310q24.1, around microsatellite marker <jats:italic>D10S185<\/jats:italic> (2.77 Mb), 23 genes were identified, including three (<jats:italic>KIF11, HHEX<\/jats:italic>, and <jats:italic>HELLS<\/jats:italic>) with functions that, if dysregulated, could be critical in MF and SS. The second region of deletion, 10q24.33\u201310q25.1, around microsatellite marker <jats:italic>D10S530<\/jats:italic> (3.92 Mb), encodes 11 genes, the majority of which have poorly identified functions. This extensive allelotyping study provides the basis for future highly selective candidate gene analyses. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20115","type":"journal-article","created":{"date-parts":[[2004,11,11]],"date-time":"2004-11-11T23:48:27Z","timestamp":1100216907000},"page":"184-192","source":"Crossref","is-referenced-by-count":38,"title":["Fine mapping of chromosome 10q deletions in mycosis fungoides and sezary syndrome: Identification of two discrete regions of deletion at 10q23.33\u201324.1 and 10q24.33\u201325.1"],"prefix":"10.1002","volume":"42","author":[{"given":"E. 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