{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:50:57Z","timestamp":1761918657690},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,19]],"date-time":"2004-10-19T00:00:00Z","timestamp":1098144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytogenetic abnormalities at the 12q12\u2010q14 chromosomal locus are rarely detected in acute lymphoblastic leukemia (ALL). To examine submicroscopic deletions at this locus, we analyzed 78 adult precursor B\u2010 and T\u2010cell ALL cases [27 with Philadelphia chromosome (Ph)\u2013negative B\u2010cell ALL, 20 with Ph\u2010negative B\u2010cell ALL with expression of one or two myeloid markers, 18 with Ph\u2010positive B\u2010cell ALL, and 13 with T\u2010cell ALL] using a panel of 13 microsatellite (MST) markers that span the 12q12\u2013q14.3 region. The status of MST markers was evaluated by use of polymerase chain reaction performed with fluorescence\u2010labeled primers and automated fragment analysis. The MST marker analyses showed submicroscopic deletions at the 12q14.3 locus in 20 of the 78 ALL cases (26%). The frequency of deletions was highest in Ph\u2010negative B\u2010cell ALL (13 of 27, 48%) compared with that in Ph\u2010negative B\u2010cell ALL with expression of myeloid markers (4 of 20, 20%), Ph\u2010positive B\u2010cell ALL (2 of 18, 11%), and T\u2010cell ALL (1 of 13, 8%). Deletion frequencies of MST markers along the 12q12\u2013q14.3 locus suggest that the targeted gene of deletion is located within a 170\u2010kb region bordered by the markers <jats:italic>D12S1504<\/jats:italic> (approximately 65 kb upstream of <jats:italic>HMGA2<\/jats:italic>) and <jats:italic>D12S1509<\/jats:italic> (in intron 3 of <jats:italic>HMGA2<\/jats:italic>) at the 12q14.3 locus. These submicroscopic deletions at the 12q14.3 locus may play a role in the pathogenesis of ALL, particularly in Ph\u2010negative precursor B\u2010cell ALL. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20116","type":"journal-article","created":{"date-parts":[[2004,10,20]],"date-time":"2004-10-20T11:50:31Z","timestamp":1098273031000},"page":"87-94","source":"Crossref","is-referenced-by-count":8,"title":["Frequent deletions at 12q14.3 chromosomal locus in adult acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"42","author":[{"given":"Hemantkumar S.","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagop M.","family":"Kantarjian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos E.","family":"Bueso\u2010Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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