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This report is on the cytogenetics of a large series of 111 hepatoblastoma specimens, with cytogenetic results consecutively karyotyped over a 12\u2010year period. Abnormal karyotypes were observed in 55 cases (\u223c50% of the total). Numerical aberrations were observed in 41 cases (36% of the total), particularly trisomies of chromosomes 2, 8, and 20. Chromosome losses were less common than chromosome gains. Structural abnormalities were observed in 43 cases (39% of the total). Unbalanced translocations resulting in trisomy 1q and involving breakpoints at 1q12\u201321 were the most common structural abnormality, observed in 20 tumors (18% of total cases); the corresponding translocated chromosome was highly varied. The previously reported t(1;4) was observed in seven cases. Most tumors with translocations involving 1q12\u201321 also displayed numerical chromosome aberrations, the most common of which were chromosomal trisomies, whereas tumors with other structural rearrangements had fewer numerical abnormalities. Supplementary material for this article can be found on the Genes, Chromosomes, and Cancer website at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.interscience.wiley.com\/jpages\/1045-2257\/suppmat\/index.html\">http:\/\/www.interscience.wiley.com\/jpages\/1045\u20102257\/suppmat\/index.html<\/jats:ext-link>. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20227","type":"journal-article","created":{"date-parts":[[2005,6,24]],"date-time":"2005-06-24T20:17:33Z","timestamp":1119644253000},"page":"177-184","source":"Crossref","is-referenced-by-count":74,"title":["Cytogenetic evaluation of a large series of hepatoblastomas: Numerical abnormalities with recurring aberrations involving 1q12\u2013q21"],"prefix":"10.1002","volume":"44","author":[{"given":"Gail E.","family":"Tomlinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin 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