{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:53:00Z","timestamp":1791118380852,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,7,27]],"date-time":"2005-07-27T00:00:00Z","timestamp":1122422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Natural killer (NK) cell lymphomas\/leukemias are highly aggressive lymphoid malignancies, but little is known about their genomic alterations, and thus there is an urgent need for identification and analysis of NK cell lymphomas\/leukemias. Recently, we developed our own array\u2010based comparative genomic hybridization (array CGH) with an average resolution of 1.3 Mb. We performed an array CGH analysis for 27 NK\u2010cell lymphoma\/leukemia cases that were classified into two disease groups based on the World Health Organization Classification (10 aggressive NK\u2010cell leukemia cases and 17 extranodal NK\/T\u2010cell [NK\/T] lymphomas, nasal type). We identified the differences in the genomic alteration patterns of the two groups. The recurrent regions characteristic of the aggressive NK\u2010cell leukemia group compared with those of the extranodal NK\/T lymphoma, nasal\u2010type group, were gain of 1q and loss of 7p15.1\u2010p22.3 and 17p13.1. In particular, gain of 1q23.1\u201024.2 (<jats:italic>P<\/jats:italic> = 0.041) and 1q31.3\u2010q44 (<jats:italic>P<\/jats:italic> = 0.003\u20130.047), and loss of 7p15.1\u2010p22.3 (<jats:italic>P<\/jats:italic> = 0.012\u20130.041) and 17p13.1 (<jats:italic>P<\/jats:italic> = 0.012) occurred significantly more frequently in the former than in the latter group. Recurrent regions characteristic of the extranodal NK\/T lymphoma, nasal\u2010type group, compared with those of the other group were gain of 2q, and loss of 6q16.1\u2010q27, 11q22.3\u2010q23.3, 5p14.1\u2010p14.3, 5q34\u2010q35.3, 1p36.23\u2010p36.33, 2p16.1\u2010p16.3, 4q12, and 4q31.3\u2010q32.1. Our results can be expected to provide further insights into the genetic basis of lymphomagenesis and the clinicopathologic features of NK\u2010cell lymphomas\/leukemias. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20245","type":"journal-article","created":{"date-parts":[[2005,7,27]],"date-time":"2005-07-27T15:33:58Z","timestamp":1122478438000},"page":"247-255","source":"Crossref","is-referenced-by-count":182,"title":["Genome\u2010wide array\u2010based comparative genomic hybridization of natural killer cell lymphoma\/leukemia: Different genomic alteration patterns of aggressive NK\u2010cell leukemia and extranodal Nk\/T\u2010cell lymphoma, nasal type"],"prefix":"10.1002","volume":"44","author":[{"given":"Yasuhiro","family":"Nakashima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Tagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritsuro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivasundaram","family":"Karnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kennosuke","family":"Karube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Muta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Nawata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Morishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Seto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.12.4501"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.7.1781.1781"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.2.613"},{"key":"e_1_2_6_6_1","first-page":"2775","article-title":"Deletion of 6q16\u2010q21 in human lymphoid malignancies: a mapping and deletion analysis","volume":"60","author":"Jackson A","year":"2000","journal-title":"Cancer Res"},{"issue":"1","key":"e_1_2_6_7_1","first-page":"S8","article-title":"World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues. A progress report","volume":"111","author":"Jaffe ES","year":"1999","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_6_8_1","first-page":"191","volume-title":"World Health Organization Classification of Tumors","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.1069"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1182\/blood.V91.9.3397","article-title":"6q deletions in acute lymphoblastic leukemia and non\u2010Hodgkin's lymphomas","volume":"91","author":"Merup M","year":"1998","journal-title":"Blood"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190290006062"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3773"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/2524"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65454-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64818-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1182\/blood.V95.4.1180.004k14_1180_1187","article-title":"Genomic aberrations common in gastric high\u2010grade large B\u2010cell lymphoma","volume":"95","author":"Starostik P","year":"2000","journal-title":"Blood"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04419.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-4056"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.3223139.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199909050949"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(02)00065-6"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/1042819031000123410"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.20245","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.20245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T17:43:13Z","timestamp":1697478193000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.20245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,27]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1002\/gcc.20245"],"URL":"https:\/\/doi.org\/10.1002\/gcc.20245","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7,27]]}}}